Does chronic physical activity level modify the airway inflammatory response to an acute bout of exercise in the post-prandial period?
| Autor: | Sara K. Rosenkranz, Stephanie P. Kurti, Colby S. Teeman, Morton H. Levitt, Sam R. Emerson, Brooke J. Cull, Craig A. Harms, Joshua R. Smith, Stephen K. Chapes |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Endocrinology Diabetes and Metabolism Period (gene) Inflammatory response Respiratory Mucosa Walking 030204 cardiovascular system & hematology Diet High-Fat Nitric Oxide Article Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Oxygen Consumption Physiology (medical) Internal medicine medicine Humans Exercise Meals Meal Nutrition and Dietetics Exercise Tolerance business.industry digestive oral and skin physiology Airway inflammation Models Immunological 030229 sport sciences General Medicine Pneumonia respiratory system Middle Aged Postprandial Period Physical activity level respiratory tract diseases Endocrinology Postprandial Breath Tests Exercise Test Female Airway business Biomarkers |
| Popis: | Recent studies have confirmed that a single high-fat meal (HFM) leads to increased airway inflammation. However, exercise is a natural anti-inflammatory and may modify postprandial airway inflammation. The postprandial airway inflammatory response is likely to be modified by chronic physical activity (PA) level. This study investigated whether chronic PA modifies the airway inflammatory response to an acute bout of exercise in the postprandial period in both insufficiently active and active subjects. Thirty-nine nonasthmatic subjects (20 active, 13 males/7 females) who exceeded PA guidelines (≥150 min moderate−vigorous PA/week) and 19 insufficiently active (6 males/13 females) underwent an incremental treadmill test to exhaustion to determine peak oxygen uptake. Subjects were then randomized to a condition (COND), either remaining sedentary (CON) or exercising (EX) post-HFM. Exercise was performed at the heart rate corresponding to 60% peak oxygen uptake on a treadmill for 1 h post-HFM (63% fat, 10 kcal/kg body weight). Blood lipids and exhaled nitric oxide (eNO: marker of airway inflammation) were measured at baseline and 2 h and 4 h post-HFM. Sputum differential cell counts were performed at baseline and 4 h post-HFM. The mean eNO response for all groups increased at 2 h post-HFM (∼6%) and returned to baseline by 4 h (p = 0.03). There was a time × COND interaction (p = 0.04), where EX had a greater eNO response at 4 h compared with CON. Sputum neutrophils increased at 4 h post-HFM (p < 0.05). These findings suggest that airway inflammation occurs after an HFM when exercise is performed in the postprandial period, regardless of habitual activity level. |
| Databáze: | OpenAIRE |
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