Multi-dimensional electrical impedance myography of the tongue as a potential biomarker for amyotrophic lateral sclerosis
| Autor: | T. Jamie Healey, Harry E. McDonough, James J.P. Alix, Pamela J. Shaw, D. Ganesh Rao, Visakan Kadirkamanathan, Sophie J French, Buket Sonbas, Christopher J McDermott |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 050105 experimental psychology 03 medical and health sciences Young Adult 0302 clinical medicine Tongue Physiology (medical) Healthy volunteers medicine Electric Impedance Disease biomarker Humans 0501 psychology and cognitive sciences Amyotrophic lateral sclerosis Muscle Skeletal Aged Aged 80 and over Electrical impedance myography business.industry 05 social sciences Amyotrophic Lateral Sclerosis Myography Reproducibility of Results Middle Aged medicine.disease Sensory Systems medicine.anatomical_structure Neurology Potential biomarkers Multi dimensional Mann–Whitney U test Disease Progression Female Neurology (clinical) Nuclear medicine business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 131(4) |
| ISSN: | 1872-8952 |
| Popis: | In amyotrophic lateral sclerosis (ALS) bulbar disease biomarkers are lacking. We evaluated a novel tongue electrical impedance myography (EIM) system, utilising both 2D and 3D electrode configurations for detection of tongue pathology.Longitudinal multi-frequency phase angle spectra were recorded from 41 patients with ALS (baseline, 3 and 6 months) and 30 healthy volunteers (baseline and 6 months). ALS functional rating scale-revised (ALSFRS-R) data and quantitative tongue strength measurements were collected. EIM data were analysed for reliability (intra-class correlation coefficient; ICC) and differences between patients and volunteers ascertained using both univariate (Mann-Whitney U test) and multivariate techniques (feature selection and L2 norm).The device produced highly reliable data (pooled ICC: 0.836). Significant EIM differences were apparent between ALS patients and healthy volunteers (P 0.001). EIM data demonstrated a significant relationship to tongue strength and bulbar ALSFRS-R scores (P 0.015). The EIM recordings revealed a group level longitudinal change over 6 months and consistently identified patients in whom symptoms or tongue strength changed.The novel EIM tongue system produces reliable data and can differentiate between healthy muscle and ALS-related disease.Tongue EIM utilising multiple frequencies and electrode configurations has potential as a bulbar disease biomarker in ALS. |
| Databáze: | OpenAIRE |
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