The current status of FLASH particle therapy: a systematic review

Autor: Jake Atkinson, Eva Bezak, Hien Le, Ivan Kempson
Přispěvatelé: Atkinson, Jake, Bezak, Eva, Le, Hien, Kempson, Ivan
Rok vydání: 2023
Předmět:
Zdroj: Physical and Engineering Sciences in Medicine. 46:529-560
ISSN: 2662-4737
2662-4729
DOI: 10.1007/s13246-023-01266-z
Popis: Particle therapies are becoming increasingly available clinically due to their beneficial energy deposition profile, sparing healthy tissues. This may be further promoted with ultra-high dose rates, termed FLASH. This review comprehensively summarises current knowledge based on studies relevant to proton- and carbon-FLASH therapy. As electron-FLASH literature presents important radiobiological findings that form the basis of proton and carbon-based FLASH studies, a summary of key electron-FLASH papers is also included. Preclinical data suggest three key mechanisms by which proton and carbon-FLASH are able to reduce normal tissue toxicities compared to conventional dose rates, with equipotent, or enhanced, tumour kill efficacy. However, a degree of caution is needed in clinically translating these findings as: most studies use transmission and do not conform the Bragg peak to tumour volume; mechanistic understanding is still in its infancy; stringent verification of dosimetry is rarely provided; biological assays are prone to limitations which need greater acknowledgement.
Databáze: OpenAIRE
Externí odkaz: