miR-1297 Promotes Cell Proliferation of Non-Small Cell Lung Cancer Cells: Involving in PTEN/Akt/Skp2 Signaling Pathway
| Autor: | Tianyou Luo, Wenjin Bu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lung Neoplasms Cell Apoptosis 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung microRNA Genetics medicine SKP2 Biomarkers Tumor Tumor Cells Cultured PTEN Tensin Humans Molecular Biology Protein kinase B S-Phase Kinase-Associated Proteins Cell Proliferation A549 cell biology Oncogene PTEN Phosphohydrolase Cell Biology General Medicine Molecular biology respiratory tract diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Case-Control Studies biology.protein Cancer research Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | DNA and cell biology. 36(11) |
| ISSN: | 1557-7430 |
| Popis: | Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a lipid and protein phosphatase and possesses an antitumor effect in lung cancers. miRNAs are reportedly abnormally expressed in human lung cancers. However, whether miRNA contributes to PTEN expression in non-small cell lung cancers (NSCLCs) has not been clearly clarified. In the present study, we found that miR-1297 probably binds with 3'UTR sequence of PTEN and negatively regulated the levels of PTEN in NSCLC cells. First, the expression levels of PTEN and Skp2 were detected by western blotting in NSCLC specimens and paired normal tissue specimens. The results showed that decreased levels of PTEN were detected in NSCLC tissues, compared with paired control tissues (**p |
| Databáze: | OpenAIRE |
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