Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis
| Autor: | Tomoya Ikeda, Takaki Ishikawa, Naoto Tani, William H. Hoffman, James E. Blum, Carol M. Artlett |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Glycation End Products
Advanced Male endocrine system diseases Endocrinology Diabetes and Metabolism Metabolite Receptor for Advanced Glycation End Products 030204 cardiovascular system & hematology Severity of Illness Index lcsh:Diseases of the endocrine glands. Clinical endocrinology Gastroenterology d-lactate RAGE (receptor) chemistry.chemical_compound diabetic ketoacidosis 0302 clinical medicine Endocrinology Glycation Insulin Longitudinal Studies Child soluble receptor for advanced glycation end-products Receptor Methylglyoxal lcsh:RJ1-570 Treatment Outcome Female Original Article medicine.symptom medicine.medical_specialty Adolescent Diabetic ketoacidosis 030209 endocrinology & metabolism Inflammation 03 medical and health sciences Internal medicine medicine Humans Hypoglycemic Agents Lactic Acid Type 1 diabetes lcsh:RC648-665 business.industry nutritional and metabolic diseases lcsh:Pediatrics medicine.disease Diabetes Mellitus Type 1 chemistry Pediatrics Perinatology and Child Health myocarditis business |
| Zdroj: | JCRPE, Vol 12, Iss 2, Pp 160-167 (2020) Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| Popis: | Objective To determine the time relationships of soluble receptor for glycation end-products (sRAGE), [a decoy of the advanced glycation end-products (AGE)-RAGE axis] and D-lactate, (a metabolite of methylglyoxal) in the inflammatory response to diabetic ketoacidosis (DKA). Methods Sixteen children and adolescents with type 1 diabetes (T1D) had blood samples obtained, 6-12 hours into treatment, at three weeks and three months post start of treatment. sRAGE and D-lactate concentrations at three months were considered baseline. Expression of RAGE was investigated in the myocardium of a newly diagnosed and untreated young person with fatal T1D/DKA. Results sRAGE 6-12 hours after the start of treatment was 39% lower than the values at two weeks (p=0.0036) and at three months (p=0.0023) post treatment. D-lactate was higher during treatment than at three weeks (p=0.04) and at three months (p=0.035). Conclusion sRAGE concentration was decreased during treatment, compared to concentrations at two weeks and three months after treatment. The increased D-lactate during treatment was in keeping with the known increase in dicarbonyls at this time. The finding of RAGE expression in a young myocardium prior to DKA treatment suggested cardiovascular inflammation pre-treatment and at a young age. |
| Databáze: | OpenAIRE |
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