Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study
| Autor: | Frauke Zipp, Jan Dörr, Stephanie Ohlraun, Caspar F. Pfueller, Friedemann Paul, Markus Bock, Alexander U. Brandt |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Time Factors genetic structures Visual Acuity Standard deviation Young Adult chemistry.chemical_compound Nuclear magnetic resonance Optical coherence tomography Predictive Value of Tests Germany Image Interpretation Computer-Assisted medicine Humans Time domain Physics Reproducibility Chi-Square Distribution medicine.diagnostic_test Multiple sclerosis Resolution (electron density) Retinal Equipment Design Middle Aged medicine.disease Axons eye diseases Surgery Cross-Sectional Studies Neurology chemistry Case-Control Studies Linear Models Female sense organs Neurology (clinical) Tomography Tomography Optical Coherence Retinal Neurons |
| Zdroj: | Multiple Sclerosis Journal. 16:893-896 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458510365156 |
| Popis: | Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has not been investigated in multiple sclerosis. In this study involving 55 multiple sclerosis patients, data obtained using both techniques (Stratus time domain optical coherence tomography and Cirrus spectral domain optical coherence tomography, Carl Zeiss Meditec) showed an excellent correlation (Pearson’s r = 0.926, p < 0.001). However, owing to considerable differences in absolute retinal nerve fibre layer measurements (mean ± standard deviation 8.1 µm ± 6.2, range -12 to 23 µm), results from the two devices are not interchangeable. |
| Databáze: | OpenAIRE |
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