Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors

Autor:	Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
Rok vydání:	2003
Předmět:	Farnesyl Protein Transferase Stereochemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science Quinolones Biochemistry Chemical synthesis Structure-Activity Relationship In vivo Drug Discovery Animals Farnesyltranstransferase Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Farnesyl-diphosphate farnesyltransferase Alkyl and Aryl Transferases Molecular Structure biology organic chemicals Organic Chemistry In vitro Kinetics Enzyme chemistry Enzyme inhibitor Drug Design Quinazolines Quinolines biology.protein Molecular Medicine Cell Division
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
ISSN:	0960-894X
Popis:	A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for oral in vivo inhibition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d7d9eb0ec5e2c21ab43464526d04f9 https://doi.org/10.1016/j.bmcl.2003.08.080 Zobrazit plný text záznamu Full Text from ScienceDirect