Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis
| Autor: | Tibor T. Glant, Tamas Koreny, Csaba Vermes, Miklos Tunyogi-Csapo, Joshua J. Jacobs, Jorge O. Galante |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Angiogenesis Joint Prosthesis Gene Expression Periprosthetic chemistry.chemical_compound Phagocytosis Osteoprotegerin medicine Humans Orthopedics and Sports Medicine RNA Messenger Arthroplasty Replacement Particle Size Fibroblast Cells Cultured Aged Aged 80 and over Titanium Neovascularization Pathologic biology Monocyte Synovial Membrane Fibroblasts Middle Aged Vascular endothelial growth factor Drug Combinations medicine.anatomical_structure chemistry RANKL Cancer research biology.protein Angiogenesis Inducing Agents Female Chemokines Transforming growth factor |
| Zdroj: | Journal of Orthopaedic Research. 25:1378-1388 |
| ISSN: | 0736-0266 |
| DOI: | 10.1002/jor.20449 |
| Popis: | The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule-like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth factors alone or in combination (e.g., in conditioned media of explant cultures of IFMs) stimulated normal synovial and IFM fibroblasts to express inflammatory mediators and growth factors such as interleukin (IL)-1β, IL-6, IL-8, three isoforms of vascular endothelial growth factor (VEGF), monocyte/macrophage chemoattractant protein-1 (MCP-1), macrophage-colony-stimulating factor (M-CSF), cycloxygenases (Cox-1 and Cox-2), acid- and basic-fibroblast growth factors (FGF-1 and FGF-2), leukemia inhibitory factor-1 (LIF-1), transforming growth factor β-1 (TGF-β1), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG). Thus, the fibroblast is capable of expressing a wide array of angiogenic and osteoclastogenic factors which are involved in the detrimental processes of the periprosthetic osteolysis. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1378–1388, 2007 |
| Databáze: | OpenAIRE |
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