Functional and Structural Changes in the Corticospinal Tract of Streptozotocin-Induced Diabetic Rats
| Autor: | Satoshi Shimo, Masako Ikutomo, Ken Muramatsu, Masatoshi Niwa, Toru Tamaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Pathology medicine.medical_specialty corticospinal tract Diabetic neuropathy QH301-705.5 Neural Conduction Pyramidal Tracts Action Potentials Streptozocin Article Catalysis Nerve conduction velocity Diabetes Mellitus Experimental Inorganic Chemistry Atrophy Diabetes mellitus medicine Animals Biology (General) Rats Wistar Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Motor Neurons diabetes business.industry Body Weight Organic Chemistry General Medicine Streptozotocin medicine.disease Spinal cord diabetic neuropathy Computer Science Applications Chemistry Lumbar Spinal Cord medicine.anatomical_structure Spinal Cord Corticospinal tract business medicine.drug |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 18 International Journal of Molecular Sciences, Vol 22, Iss 10123, p 10123 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms221810123 |
| Popis: | This study aimed to reveal functional and morphological changes in the corticospinal tract, a pathway shown to be susceptible to diabetes. Type 1 diabetes was induced in 13-week-old male Wistar rats administered streptozotocin. Twenty-three weeks after streptozotocin injection, diabetic animals and age-matched control animals were used to demonstrate the conduction velocity of the corticospinal tract. Other animals were used for morphometric analyses of the base of the dorsal funiculus of the corticospinal tract in the spinal cord using both optical and electron microscopy. The conduction velocity of the corticospinal tract decreased in the lumbar spinal cord in the diabetic animal, although it did not decrease in the cervical spinal cord. Furthermore, atrophy of the fibers of the base of the dorsal funiculus was observed along their entire length, with an increase in the g-ratio in the lumbar spinal cord in the diabetic animal. This study indicates that the corticospinal tract fibers projecting to the lumbar spinal cord experience a decrease in conduction velocity at the lumbar spinal cord of these axons in diabetic animals, likely caused by a combination of axonal atrophy and an increased g-ratio due to thinning of the myelin sheath. |
| Databáze: | OpenAIRE |
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