Proanthocyanidins from the Bark ofHamamelis virginianaExhibit Antimutagenic Properties against Nitroaromatic Compounds
| Autor: | Oskar Schimmer, Petra Metzner, Andreas Dauer |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmaceutical Science
Analytical Chemistry Ames test Anthocyanins chemistry.chemical_compound Drug Discovery medicine Gallocatechin Organic chemistry Proanthocyanidins Pharmacology Fluorenes Organic Chemistry Tincture Antimutagenic Agents Catechin Plants Hamamelis virginiana Complementary and alternative medicine chemistry Proanthocyanidin visual_art visual_art.visual_art_medium Molecular Medicine Bark Antimutagen Mutagens medicine.drug |
| Zdroj: | Planta Medica. 64:324-327 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-957443 |
| Popis: | The antimutagenic activity of Hamamelis virginiana bark was examined in the Ames assay. A commercial tincture and a methanolic extract showed dose-dependent inhibitory effects on mutagenicity induced by 2-nitrofluorene. Tannin-free samples did not display any inhibition. Bioassay-guided fractionation resulted in the isolation of two active fractions which were shown to contain oligomeric, proanthocyanidins. They were capable of inhibiting the mutagenicity of selected nitroaromatic compounds. The mechanism of antimutagenic action was also studied. The proanthocyanidins did not act as bioantimutagens, but rather as direct-acting desmutagens. The antimutagenic effect increased with an increasing degree of polymerisation in the proanthocyanidins. The most active fraction consisted of catechin and gallocatechin oligomers with an average polymerisation degree of 9.2. |
| Databáze: | OpenAIRE |
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