Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury
| Autor: | Cinzia Allegrucci, Albert Anatolevich Rizvanov, D. Andreeva, Alina Zeinalova, Valeriia Syromiatnikova, A. A. Bogov, Adilet Abdullaatovich Kadyrov, Galina Masgutova, Ruslan Masgutov, Ilnur I. Salafutdinov, Kamilla Idrisova, Ekaterna Evgenievna Garanina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Angiogenesis
medicine.medical_treatment Review Fibroblast growth factor nerve growth factor chemistry.chemical_compound Developmental Neuroscience Neurotrophic factors peripheral nervous system growth factors Medicine peripheral nerve injury RC346-429 fibroblast growth factor 2 biology vascular endothelial growth factor business.industry Growth factor Vascular endothelial growth factor Nerve growth factor chemistry Peripheral nerve injury biology.protein Neurology. Diseases of the nervous system business Neuroscience Neurotrophin |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 17, Iss 6, Pp 1240-1247 (2022) |
| ISSN: | 1876-7958 1673-5374 |
| Popis: | The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability. Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells. This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth, including neurotrophic factors and extracellular matrix proteins. Each growth factor plays its own specific angiotrophic or neurotrophic role. Currently, growth factors are widely studied as accelerators of nerve regeneration. Particularly noteworthy is synergy between various growth factors, that is essential for both angiogenesis and neurogenesis. Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects. At the same time, fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system. Taken together, their neurotrophic and angiogenic properties have positive effect on the regeneration process. In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves, thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system. |
| Databáze: | OpenAIRE |
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