Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature
| Autor: | Abdul Kasem, Kefah Mokbel, Reham Almukbel, Hannah Headon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Axillary lymph nodes medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine business.industry Cancer Articles medicine.disease Surgery Radiation therapy 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Meta-analysis Relative risk Lymph business Mastectomy |
| Zdroj: | Molecular and Clinical Oncology. 5:429-436 |
| ISSN: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2016.971 |
| Popis: | In breast cancer with >4 positive axillary lymph nodes, it is common practice to deliver radiotherapy to the affected site following mastectomy. However, less is known regarding the benefits this may confer on women with 1–3 positive lymph nodes. In this meta-analysis, we aimed to assess whether post-mastectomy radiotherapy (PMRT) was beneficial for such patients. A literature review was conducted using the PubMed and Ovid databases. Selected studies were analysed and data regarding overall survival (OS) and locoregional recurrence (LRR) rates were extracted. Statistical analysis was then conducted in order to develop a combined risk ratio (RR) for both OS and LRR in the setting of PMRT in women with breast cancer with 1–3 positive lymph nodes. PMRT in women with 1–3 positive lymph nodes significantly reduced the risk of LRR, with a RR of 0.3 [95% confidence interval (CI): 0.23–0.38] and also showed a minor benefit in terms of OS (RR=1.03, 95% CI: 1.00–1.07). Therefore, in breast cancer patients with 1–3 positive lymph nodes, PMRT significantly reduced the risk of LRR and was associated with a minor OS benefit. Until the results of ongoing randomised controlled trials are published, PMRT should be recommended in this group of patients following a careful multidisciplinary discussion. |
| Databáze: | OpenAIRE |
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