Intracerebral xenotransplantation of semipermeable membrane- encapsuled pancreatic islets
| Autor: | Song-Lin Ge, Han-Tao Hu, Xiao-Kang Wu, Zhao-Liang Xin, Yan-Jie Jia |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty Xenotransplantation medicine.medical_treatment Transplantation Heterologous Cell Islets of Langerhans Transplantation Rats Sprague-Dawley Islets of Langerhans Dogs Internal medicine medicine Animals Loose connective tissue Chemistry Foreign-Body Reaction Pancreatic islets Graft Survival Gastroenterology Brain General Medicine medicine.disease In vitro Rats Endocrinology medicine.anatomical_structure Apoptosis Brief Reports Epithelioid cell Infiltration (medical) |
| Zdroj: | World Journal of Gastroenterology. 11:5714 |
| ISSN: | 1007-9327 |
| Popis: | AIM: To identify the decreasing effect of xenotransplantion in combination with privileged sites on rejection and death of biological semipermeable membrane-(BSM) encapsulated implanted islets. METHODS: After the BSM experiment in vitro, BSMencapsulated SD rat’s islet-like cell clusters (ICCs) were xenotransplanted into normal dog’s brain. Morphological changes were observed under light and transmission electron microscope. The islets and apoptosis of implanted B cells were identified by insulin-TUNEL double staining. RESULTS: The BSM used in our study had a favorable permeability, some degree of rigidity, lighter foreign body reaction and toxicity. The grafts consisted of epithelioid cells and loose connective tissue. Severe infiltration of inflammatory cells was not observed. The implanted ICCs were identified 2 mo later and showed typical apoptosis. CONCLUSION: BSM xenotransplantation in combination with the privileged site can inhibit the rejection of implanted heterogeneous ICCs, and death of implanted heterogeneous B cells is associated with apoptosis. |
| Databáze: | OpenAIRE |
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