THE IMPORTANCE OF IDH1, ATRX AND WT-1 MUTATIONS IN GLIOBLASTOMA
| Autor: | Bahar Baltalarli, Gülsün Gülten, Gamze Gokoz Dogu, Feridun Acar, Nagihan Yalçın, Yücel Doğruel |
|---|---|
| Přispěvatelé: | info:eu-repo/semantics/openAccess |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty X-linked Nuclear Protein IDH1 medicine.medical_treatment retrospective study transcriptional regulator ATRX Genetic pathways IDH1 protein human Pathology and Forensic Medicine wt-1 Internal medicine medicine Humans genetics ATRX protein human human WT1 protein human WT1 Proteins ATRX Retrospective Studies Chemotherapy business.industry Significant difference glioblastoma glioblastorna immunohistochemistry WT-1 General Medicine medicine.disease Prognosis Immunohistochemistry Isocitrate Dehydrogenase Radiation therapy WT1 protein Mutation Medicine business Glioblastoma |
| Zdroj: | Polish Journal of Pathology, Vol 71, Iss 2, Pp 127-137 (2020) |
| Popis: | Numerous genetic pathways associated with glioblastoma development have been identified. In this study, we investigated the prognostic significance of IDH1 and ATRX mutations and WT-1 and p53 expression in glioblastomas and that of surgical methods, radiotherapy and chemotherapy. 83 patients with glioblastomas were retrospectively evaluated. Immunohistochemical analysis was performed for IDH1, ATRX and WT-1 expression. Tumour cells were positive for IDH1 in 9.6% of the patients. In 4.8% of the patients, loss of ATRX expression was observed in tumour cells; 86.7% of the patients were WT-1 positive, and 12.05% of the patients were p53 positive. No statistically significant difference was found in the progression-free and overall survival according to IDH1, ATRX, WT-1 and p53 expression. There was a statistically significant difference in the progression-free and overall survival according to the radiotherapy status. There was a statistically significant difference in the overall survival according to the chemotherapy status. There was no statistically significant difference in the progression-free and overall survival according to the surgical method. IDH1 and ATRX mutations, p53 overexpression and WT-1 expression alone did not have a significant effect on the prognosis of patients with glioblastoma; however, radiotherapy and chemotherapy had a positive effect on survival. C1 [Gulten, Gulsun; Yalcin, Nagihan] Pamukkale Univ, Pathol Dept, Fac Med, Denizli, Turkey. [Baltalarli, Bahar] Pamukkale Univ, Radiat Oncol Dept, Fac Med, Denizli, Turkey. [Dogu, Gamze Gokoz] Pamukkale Univ, Med Oncol Dept, Fac Med, Denizli, Turkey. [Acar, Feridun; Dogruel, Yucel] Pamukkale Univ, Brain Surg Dept, Fac Med, Denizli, Turkey. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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