Transcranial magnetic stimulation and BDNF plasma levels in amyotrophic lateral sclerosis
Autor: | E. Saturno, Francesco Angelucci, Anna Paola Batocchi, Pietro Attilio Tonali, Vincenzo Di Lazzaro, Viviana Versace, Antonio Oliviero, Gabriella Musumeci, Fabio Pilato, Michele Dileone |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male medicine.medical_treatment Central nervous system Neurotransmission behavioral disciplines and activities Electromagnetic Fields Reference Values mental disorders Humans Medicine Premovement neuronal activity Amyotrophic lateral sclerosis Brain-derived neurotrophic factor business.industry Brain-Derived Neurotrophic Factor musculoskeletal neural and ocular physiology General Neuroscience Amyotrophic Lateral Sclerosis Age Factors Motor Cortex Brain Human brain Middle Aged medicine.disease Transcranial Magnetic Stimulation Electric Stimulation Transcranial magnetic stimulation medicine.anatomical_structure nervous system Female business Neuroscience psychological phenomena and processes Motor cortex |
Zdroj: | NeuroReport. 15:717-720 |
ISSN: | 0959-4965 |
DOI: | 10.1097/00001756-200403220-00029 |
Popis: | Low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex results in lasting changes of excitatory neurotransmission. We investigated the effects of suprathreshold 1 Hz rTMS on brain derived neurotrophic factor (BDNF) plasma levels in 10 healthy subjects and effects of either 1 Hz or 20 Hz rTMS in four amyotrophic lateral sclerosis (ALS) patients. BDNF levels were progressively decreased by 1 Hz rTMS in healthy subjects; there was no effect of 1 Hz rTMS on BDNF plasma levels in ALS patients, an effect probably due to the loss of motor cortex pyramidal cells. High frequency rTMS determined a transitory decrease in BDNF plasma levels. Cumulatively these findings suggest that rTMS might influence the BDNF production by interfering with neuronal activity. |
Databáze: | OpenAIRE |
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