Transcranial magnetic stimulation and BDNF plasma levels in amyotrophic lateral sclerosis

Autor: E. Saturno, Francesco Angelucci, Anna Paola Batocchi, Pietro Attilio Tonali, Vincenzo Di Lazzaro, Viviana Versace, Antonio Oliviero, Gabriella Musumeci, Fabio Pilato, Michele Dileone
Rok vydání: 2004
Předmět:
Zdroj: NeuroReport. 15:717-720
ISSN: 0959-4965
DOI: 10.1097/00001756-200403220-00029
Popis: Low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex results in lasting changes of excitatory neurotransmission. We investigated the effects of suprathreshold 1 Hz rTMS on brain derived neurotrophic factor (BDNF) plasma levels in 10 healthy subjects and effects of either 1 Hz or 20 Hz rTMS in four amyotrophic lateral sclerosis (ALS) patients. BDNF levels were progressively decreased by 1 Hz rTMS in healthy subjects; there was no effect of 1 Hz rTMS on BDNF plasma levels in ALS patients, an effect probably due to the loss of motor cortex pyramidal cells. High frequency rTMS determined a transitory decrease in BDNF plasma levels. Cumulatively these findings suggest that rTMS might influence the BDNF production by interfering with neuronal activity.
Databáze: OpenAIRE