Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population
| Autor: | Yousun Chung, Dong Han Lee, Yun Ji Hong, Nam Sun Cho, Junghan Song, Eun Young Song, Sang Mee Hwang, Kyoung Un Park, Jeong Soo Park, Kyou-Sup Han, Young Sill Choi, Jeong Ran Kwon, So Yong Kwon, Jun Nyun Kim |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Serotype medicine.medical_specialty Genotype Population Blood Donors 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Antigen Internal medicine Republic of Korea medicine Humans Registries Typing education Genotyping education.field_of_study Polymorphism Genetic Hematology biology business.industry General Medicine Red blood cell medicine.anatomical_structure Blood Grouping and Crossmatching Population Surveillance Immunology Blood Group Antigens biology.protein Female Antibody business 030215 immunology |
| Zdroj: | Annals of Hematology. 95:985-991 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-016-2645-7 |
| Popis: | It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewpoint and estimated the demand for specific antigen-negative blood from a patient viewpoint. Our data will aid the establishment of a Rare Blood Program in Korea (KRBP). RBC genotyping of 419 blood donors was performed using a Lifecodes RBC/RBC-R typing kit (Immucor, Norcross, GA). A national recipient registry website has been established. Each hospital-based blood bank voluntarily enters data on antibodies detected and identified and the outcomes of specific antigen testing. We calculated the availabilities of specific antigen-negative blood components based on these registry data and predicted the prevalence of RBC antigens via RBC genotyping. The prevalences of various RBC antigens in the D-negative population were determined for the first time, and the Cartwright, Scianna, Dombrock, Colton, Landsteiner-Wiener, Cromer, and Knops blood group systems were identified. The availabilities of specific antigen-negative units differed when calculations were based on serotyping or genotyping, especially in the D-negative group. Data on the prevalences of various blood antigens are essential for estimating the availabilities of blood components that are appropriate for use by patients expressing relevant antibodies. Then, blood banks would be able to efficiently supply safe blood products. |
| Databáze: | OpenAIRE |
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