Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora
| Autor: | Suchana Wanich, Chavi Yenjai |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Clinical Biochemistry ved/biology.organism_classification_rank.species Pharmaceutical Science Antineoplastic Agents Biochemistry Flavones chemistry.chemical_compound Zingiberaceae Flavonoid derivatives Cell Line Tumor Oximes Drug Discovery Ic50 values Humans Cytotoxic T cell Benzopyrans Cytotoxicity Molecular Biology Flavonoids chemistry.chemical_classification Kaempferia parviflora Chemistry ved/biology Organic Chemistry Oxime Molecular biology Cell culture Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:2821-2823 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2010.03.054 |
| Popis: | Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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