Concomitant medications and clinical outcomes in idiopathic pulmonary fibrosis
| Autor: | Derek Weycker, Nicolas Kahn, Klaus-Uwe Kirchgaessler, Carlo Vancheri, Mark Atwood, Brett Ley, Michael Kreuter, Christopher J. Ryerson, David J. Lederer, Vincent Cottin |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Post hoc Download Disease outcome MEDLINE Comorbidity 03 medical and health sciences 0302 clinical medicine Drug Therapy medicine Humans In patient Drug Interactions 030212 general & internal medicine Agora Randomized Controlled Trials as Topic business.industry Conflict of interest respiratory system humanities Idiopathic Pulmonary Fibrosis Research Letters respiratory tract diseases 030228 respiratory system Family medicine Combination Drug Therapy Combination Combination method business Production team |
| Zdroj: | The European Respiratory Journal |
| ISSN: | 1399-3003 |
| Popis: | Patients with idiopathic pulmonary fibrosis (IPF) frequently have a substantial burden of comorbidities [1]. Antifibrotic therapy is recommended to slow the progression of IPF [2]. Patients receiving antifibrotic therapy frequently receive concomitant medications for the management of comorbidities [1, 3–9]. Previous post hoc analyses of antacids, statins, metformin, anticoagulants and angiotensin modulators in patients with IPF enrolled in phase III randomised controlled trials (RCTs) have generated hypotheses on the impact of these treatments on IPF outcomes [3–9]. The effects of multiple concomitant medications in patients with IPF have been largely unexplored. The objective of the present analyses was to explore the association between use of combinations of frequently prescribed concomitant medications and disease outcomes in patients with IPF. This post hoc exploratory analysis found no clear associations between frequently used concomitant medication combinations and disease progression in 1450 patients with IPF enrolled in phase III trials, but several combinations may require further study. http://bit.ly/2ZzyMXR |
| Databáze: | OpenAIRE |
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