Altered Tryptophan and Neopterin Metabolism In Cancer Patients
| Autor: | Akio Hizuta, Hiromi Iwagaki, Yasuki Nitta, Noriaki Tanaka |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Crystallography business.industry Clinical Biochemistry Tryptophan Neopterin Cancer Metabolism medicine.disease Biochemistry chemistry.chemical_compound Endocrinology neopterin chemistry QD901-999 Internal medicine medicine cancer Molecular Medicine tryptophan business metabolism |
| Zdroj: | Pteridines, Vol 9, Iss 1, Pp 29-32 (1998) |
| ISSN: | 2195-4720 0933-4807 |
| DOI: | 10.1515/pteridines.1998.9.1.29 |
| Popis: | Summary Plasma 5-hydroxytryptamine (serotonin), tryptophan and neopterin levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, but decreased serotonin and tryptophan levels. IFN-γ induces a high level of indoleamine dioxvgenase (IDO), a tryptophan degrading enzyme, which in turn increases metabolism along the tryptophan- nicotinic acid pathway, resulting in decreased synthesis of serotonin. These results suggest that persistent immune activation occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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