391. Septic Arthritis and Acute Hematogenous Osteomyelitis in Children: Disease-Specific Antibiogram and Implications for Treatment

Autor:	Nisreen O Mobayed, Danita Hahn, Daniel Roadman, Anna R. Huppler, Kevin Schlidt
Rok vydání:	2019
Předmět:	medicine.medical_specialty biology business.industry medicine.drug_class Osteomyelitis Antibiotics Arthritis Kingella kingae Clindamycin biochemical phenomena metabolism and nutrition bacterial infections and mycoses Lyme Arthritis medicine.disease medicine.disease_cause biology.organism_classification Abstracts Infectious Diseases Oncology Staphylococcus aureus Internal medicine Poster Abstracts Medicine Septic arthritis business medicine.drug
Zdroj:	Open Forum Infectious Diseases
ISSN:	2328-8957
DOI:	10.1093/ofid/ofz360.464
Popis:	Background Osteomyelitis and septic arthritis are common pediatric musculoskeletal infections with potential to cause significant morbidity. Empiric antibiotic selection is made prior to the availability of microbiologic data. The aim of this study was to compare the epidemiology of osteoarticular infections (OAI) to antibiotic regimens and local antibiograms. Methods A retrospective study was performed on patients aged 6 months to 18 years with a diagnosis of septic arthritis or acute hematogenous osteomyelitis in a large, free-standing children’s hospital between July 2012 and July 2017. Exclusion criteria were chronic osteomyelitis, prior trauma or surgery at the site, noninfectious arthritis, and Lyme arthritis. Data collected from the electronic medical record included demographics, initial and discharge antibiotic therapy, and microbiologic results. Data were compared with the local antibiogram during the same time period. Results A total of 207 patients were included: 66 patients Conclusion Our study revealed high rates of clindamycin-susceptible S. aureus in older children and K. kingae and culture-negative infection in children < 4 years with OAI. Antibiotic susceptibilities differing from our institutional antibiogram suggest that disease-specific antibiograms will aid with empiric treatment decisions. Disclosures All authors: No reported disclosures.
Databáze:	OpenAIRE
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