24R,25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier
| Autor: | Harald Rösner, Burkhard Krempien, Cedomir Cosovic, Zeljka Vukelic, Slobodan Vukicevic, Ivica Kracun |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
24 25-Dihydroxyvitamin D 3 24 25 dihydroxycolecalciferol aluminum ganglioside blood brain barrier Central nervous system Encephalopathy Hippocampus Blood–brain barrier Nephrectomy law.invention Cellular and Molecular Neuroscience Reference Values law Gangliosides Internal medicine medicine Animals Uremia Ganglioside Chemistry Brain Cell Biology medicine.disease Rats Microscopy Electron Endocrinology medicine.anatomical_structure Blood-Brain Barrier Organ Specificity Astrocytes Chromatolysis Toxicity Immunology Sialic Acids Electron microscope Aluminum |
| Zdroj: | Neurochemistry International. 20:391-399 |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/0197-0186(92)90054-u |
| Popis: | The administration of aluminum (Al) to uremic rats leads to Al accumulation in different brain regions with subsequent alteration of brain gangliosides. Addition of 24R, 25-dihydroxyvitamin D3 [24R, 25-(OH)2D3] did not influence the brain Al content determined by plasma argon emission spectrometry, but prevented the decrease in brain gangliosides. By using electron microscopy and laser microprobe mass analysis, it was demonstrated that in rats given 24R, 25-(OH)2D3 together with Al, the metal was mainly kept within perivascular astrocytes of the blood-brain barrier. On the contrary, in rats given Al only, the metal was evenly distributed throughout the brain areas causing extensive demyelination, chromatolysis of nerve cells in some brain regions (hippocampus) and brain edema. Our results could find application in the prevention of Al-induced encephalopathy in patients on hemodialysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|