Relapse Prevention in Major Depressive Disorder After Successful Acute Electroconvulsive Treatment: a 6-month Double-blind Comparison of Three Fixed Dosages of Escitalopram and a Fixed Dose of Nortriptyline - Lessons from a Failed Randomised Trial of the Danish University Antidepressant Group (DUAG-7)
| Autor: | Poul Erik Buchholtz, I. M. Terp, Per Bech, Rasmus Wentzer Licht, Claus Sørensen, Lars F. Gram, Erik Roj Larsen, M. Lunde, J. Larsen, S. Z. Eftekhari, Annette Lolk, Klaus Martiny, Per Vestergaard, Per Damkier, R Klysner, B. Straasø, I. Brødsgaard, B. B. Bendsen, Ellen Margrethe Christensen, J. Holmskov, E. Refsgaard, Connie Thurøe Nielsen |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Nortriptyline Citalopram Relapse prevention Electroconvulsive therapy Double-Blind Method Internal medicine mental disorders medicine Clinical endpoint Secondary Prevention Escitalopram Humans Pharmacology (medical) Psychiatry Electroconvulsive Therapy Depression (differential diagnoses) Aged Depressive Disorder Major General Medicine Middle Aged medicine.disease Antidepressive Agents Psychiatry and Mental health Treatment Outcome Major depressive disorder Female Psychology medicine.drug |
| Zdroj: | Martiny, K, Larsen, E R, Licht, R W, Nielsen, C T, Damkier, P, Refsgaard, E, Lunde, M, Straasø, B, Christensen, E M, Lolk, A, Holmskov, J, Sørensen, C H, Brødsgaard, I, Eftekhari, S Z, Bendsen, B B, Klysner, R, Terp, I M, Larsen, J K, Vestergaard, P, Buchholtz, P E, Gram, L F, Bech, P & Danish University Antidepressant Group (DUAG*) 2015, ' Relapse Prevention in Major Depressive Disorder After Successful Acute Electroconvulsive Treatment : a 6-month Double-blind Comparison of Three Fixed Dosages of Escitalopram and a Fixed Dose of Nortriptyline-Lessons from a Failed Randomised Trial of the Danish University Antidepressant Group (DUAG-7) ', Pharmacopsychiatry. Supplement, vol. 48, no. 7, pp. 274-8 . https://doi.org/10.1055/s-0035-1565063 Martiny, K, Larsen, E R, Licht, R W, Nielsen, C T, Damkier, P, Refsgaard, E, Lunde, M, Straasø, B, Christensen, E M, Lolk, A, Kristoffersen, J H, Sørensen, C H, Brødsgaard, I, Eftekhari, S Z, Bendsen, B B, Klysner, R, Terp, I M, Larsen, J K, Vestergaard, P, Buchholtz, P E, Gram, L F, Bech, P & Danish University Antidepressant Group (DUAG*) 2015, ' Relapse Prevention in Major Depressive Disorder After Successful Acute Electroconvulsive Treatment : a 6-month Double-blind Comparison of Three Fixed Dosages of Escitalopram and a Fixed Dose of Nortriptyline-Lessons from a Failed Randomised Trial of the Danish University Antidepressant Group (DUAG-7) ', Pharmacopsychiatry, vol. 48, no. 7, pp. 274-278 . https://doi.org/10.1055/s-0035-1565063 Martiny, K, Larsen, E R, Licht, R W, Nielsen, C T, Damkier, P, Refsgaard, E, Lunde, M, Straasø, B, Christensen, E M, Lolk, A, Holmskov, J, Sørensen, C H, Brødsgaard, I, Eftekhari, S Z, Bendsen, B B, Klysner, R, Terp, I M, Larsen, J K, Vestergaard, P, Buchholtz, P E, Gram, L F, Bech, P & and Danish University Antidepressant Group (DUAG*) 2015, ' Relapse Prevention in Major Depressive Disorder After Successful Acute Electroconvulsive Treatment : a 6-month Double-blind Comparison of Three Fixed Dosages of Escitalopram and a Fixed Dose of Nortriptyline-Lessons from a Failed Randomised Trial of the Danish University Antidepressant Group (DUAG-7) ', Pharmacopsychiatry, vol. 48, no. 7, pp. 274-278 . https://doi.org/10.1055/s-0035-1565063 |
| ISSN: | 1439-0795 |
| DOI: | 10.1055/s-0035-1565063 |
| Popis: | INTRODUCTION: Electroconvulsive treatment (ECT) is an effective treatment for severe depression but carries a risk of relapse in the following months.METHODS: Major depressive disorder patients in a current episode attaining remission from ECT (17-item Hamilton Depression Rating Scale (HAM-D17) score≤9) received randomly escitalopram 10 mg, 20 mg, 30 mg or nortriptyline 100 mg as monotherapies and were followed for 6 months in a multicentre double-blind set-up. Primary endpoint was relapse (HAM-D17≥16).RESULTS: As inclusion rate was low the study was prematurely stopped with only 47 patients randomised (20% of the planned sample size). No statistically significant between-group differences could be detected. When all patients receiving escitalopram were compared with those receiving nortriptyline, a marginal superiority of nortriptyline was found (p=0.08). One third of patients relapsed during the study period, and one third completed.DISCUSSION: Due to small sample size, no valid efficacy inferences could be made. The outcome was poor, probably due to tapering off of non-study psychotropic drugs after randomisation; this has implications for future study designs. ClinicalTrials.gov Identifier: NCT00660062. |
| Databáze: | OpenAIRE |
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