Long-term treatment with gabapentin for partial epilepsy
| Autor: | Teresa Chmelir, Jan Wallace, Nancy R. Temkin, Barbara A. Ricker, Linda M. Ojemann, Alan J. Wilensky |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Long term treatment Time Factors Gabapentin Adolescent Cyclohexanecarboxylic Acids medicine.medical_treatment Acetates Epilepsy Double-Blind Method medicine Humans Amines gamma-Aminobutyric Acid Partial epilepsy Chemotherapy partial seizures business.industry Middle Aged medicine.disease Anticonvulsant Neurology Research Design Anesthesia Toxicity Anticonvulsants Drug Therapy Combination Female Neurology (clinical) Epilepsies Partial business medicine.drug |
| Zdroj: | Epilepsy research. 13(2) |
| ISSN: | 0920-1211 |
| Popis: | Gabapentin was studied as an open-label ‘add-on’ antiepileptic drug in 35 patients with partial seizures. Follow-up at 6 months, 12 months, 18 months, and 24 months is reported. There was a trend toward improvement in simple (SPS) and complex partial seizures with it reaching significance for SPS at 12 and 24 months and for the weighted combination of seizures at 3 months. Five of nine patients were subsequently successfully converted to gabapentin monotherapy. Of those five, one is now seizure free and three are significantly improved since baseline. One remains with unchanged seizure frequency compared to baseline, but is experiencing less toxicity than at that time. This long-term observation suggests that the short-term effect demonstrated in blinded studies continues and that indeed some patients with refractory epilepsy can be maintained on gabapentin alone. Based on these findings, double-blind monotherapy trials of this drug are presently being conducted. |
| Databáze: | OpenAIRE |
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