A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body-A Prospective Pilot Study
| Autor: | Mateen Moghbel, Thomas Werner, Natalie Spaccarelli, Judith Green-McKenzie, Jayaram K. Udupa, Marcus D. Goncalves, Drew A. Torigian, Frances S. Shofer, Clementina Mesaros, Saied Gholami, Xianling Liu, Grace Choi, Abass Alavi, Yubing Tong, Prithvi Shiva Kumar, Andrew A. Strasser, Ami H. Parekh, Catherine E. Smith |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Thyroid Gland Adipose tissue Standardized uptake value Pilot Projects Intra-Abdominal Fat Gastroenterology Article 030218 nuclear medicine & medical imaging Cigarette Smoking 03 medical and health sciences 0302 clinical medicine Lumbar Bone Marrow Fluorodeoxyglucose F18 medicine.artery Internal medicine Positron Emission Tomography Computed Tomography Testis medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Muscle Skeletal Lung Aorta Subclinical infection Skin business.industry Myocardium Thyroid Brain Heart Middle Aged medicine.anatomical_structure Liver Case-Control Studies Feasibility Studies Bone marrow Radiopharmaceuticals business Nuclear medicine 030217 neurology & neurosurgery Spleen |
| Zdroj: | Academic radiology. 24(8) |
| ISSN: | 1878-4046 |
| Popis: | Rationale and Objectives The aim of this study was to assess the feasibility of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. Materials and Methods Twenty healthy male subjects (10 nonsmokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination, urine testing for oxidative stress, and serum testing. The organs of interest (thyroid, skin, skeletal muscle, aorta, heart, lung, adipose tissue, liver, spleen, brain, lumbar spinal bone marrow, and testis) were analyzed on FDG-PET/CT images to determine their metabolic activities using standardized uptake value (SUV) or metabolic volumetric product (MVP). Measurements were compared between subject groups using two-sample t tests or Wilcoxon rank-sum tests as determined by tests for normality. Correlational analyses were also performed. Results FDG-PET/CT revealed significantly decreased metabolic activity of lumbar spinal bone marrow (MVPmean: 29.8 ± 9.7 cc vs 40.8 ± 11.6 cc, P = 0.03) and liver (SUVmean: 1.8 ± 0.2 vs 2.0 ± 0.2, P = 0.049) and increased metabolic activity of visceral adipose tissue (SUVmean: 0.35 ± 0.10 vs 0.26 ± 0.06, P = 0.02) in chronic smokers compared to nonsmokers. Normalized visceral adipose tissue volume was also significantly decreased ( P = 0.04) in chronic smokers. There were no statistically significant differences in the metabolic activity of other assessed organs. Conclusions Subclinical organ effects of chronic tobacco use are detectable and quantifiable on FDG-PET/CT. FDG-PET/CT may, therefore, play a major role in the study of systemic toxic effects of tobacco use in organs of the whole body for clinical or research purposes. |
| Databáze: | OpenAIRE |
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