Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
| Autor: | Richard J. McMurtrey |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cellular differentiation Cell Comprehensive Review Context (language use) Cell Communication Regenerative medicine Diffusion 03 medical and health sciences medicine stem cell signaling Animals Humans Diffusion (business) organoids Cell Proliferation Molecular diffusion Tissue Engineering Chemistry Stem Cells diffusion gradients mass transport Cell Differentiation Cell Biology Hematology Models Theoretical 030104 developmental biology medicine.anatomical_structure Biophysics Stem cell Concentration gradient tissue development Developmental Biology Signal Transduction |
| Zdroj: | Stem Cells and Development |
| ISSN: | 1557-8534 |
| Popis: | Recent advancements in the ability to construct three-dimensional (3D) tissues and organoids from stem cells and biomaterials have not only opened abundant new research avenues in disease modeling and regenerative medicine but also have ignited investigation into important aspects of molecular diffusion in 3D cellular architectures. This article describes fundamental mechanics of diffusion with equations for modeling these dynamic processes under a variety of scenarios in 3D cellular tissue constructs. The effects of these diffusion processes and resultant concentration gradients are described in the context of the major molecular signaling pathways in stem cells that both mediate and are influenced by gas and nutrient concentrations, including how diffusion phenomena can affect stem cell state, cell differentiation, and metabolic states of the cell. The application of these diffusion models and pathways is of vital importance for future studies of developmental processes, disease modeling, and tissue regeneration. |
| Databáze: | OpenAIRE |
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