Compositional Analysis of Drugs by Laser-Induced Breakdown Spectroscopy

Autor: Sid Ahmed Beldjilali, T. Baba-Hamed, Ahmed Belasri, Jörg Hermann, Emanuel Axente
Přispěvatelé: Université des sciences et de la Technologie d'Oran Mohamed Boudiaf [Oran] (USTO MB), Laser Departement (NILPRP), NILPRP, Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Applied Spectroscopy
Journal of Applied Spectroscopy, 2017, 84 (3), pp.472-477. ⟨10.1007/s10812-017-0494-3⟩
Journal of Applied Spectroscopy, Springer Verlag, 2017, 84 (3), pp.472-477. ⟨10.1007/s10812-017-0494-3⟩
ISSN: 0021-9037
1573-8647
DOI: 10.1007/s10812-017-0494-3⟩
Popis: International audience; The feasibility of the compositional analysis of drugs by calibration-free laser-induced breakdown spectroscopy(LIBS) was investigated using multivitamin tablets as a sample material. The plasma was produced by a frequencyquadrupled Nd:YAG laser delivering UV pulses with a duration of 5 ns and an energy of 12 mJ, operated at a repetition rate of 10 Hz. The relative fractions of the elements composing the multivitamin drug were determined by comparing the emission spectrum of the laser-produced plume with the spectral radiance computed for a plasma in a local thermodynamic equilibrium. Fair agreement of the measured fractions with those given by the manufacturer was observed for all elements mentioned in the leafl et of the drug. Additional elements such as Ca, Na, Sr, Al, Li, K, and Si were detected and quantifi ed. The present investigations demonstrate that laser-induced breakdown spectroscopy is a viable technique for the quality control of drugs.
Databáze: OpenAIRE
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