Midazolam Premedication Facilitates Mask Ventilation During Induction of General Anesthesia: A Randomized Clinical Trial
| Autor: | Bo-Young Kim, Sung Hee Han, Jung-Won Hwang, Seong Joo Park, Jin Woo Park, Byung Hun Min, Sung Il Bae, Jin Hee Kim |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Time Factors medicine.drug_class Seoul Midazolam Premedication Anesthesia General Placebo Drug Administration Schedule law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial 030202 anesthesiology law Medicine Humans Elective surgery business.industry Equipment Design Middle Aged Respiration Artificial Confidence interval Anesthesiology and Pain Medicine Treatment Outcome Neuromuscular Agents Sedative Anesthesia Female business Airway 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Anesthesia and analgesia. 129(2) |
| ISSN: | 1526-7598 |
| Popis: | BACKGROUND During induction of general anesthesia, proper mask ventilation is crucial for supplying sufficient oxygen to unconscious patients. Midazolam has a relaxing effect on airway muscles. We hypothesized that sedative premedication with midazolam would facilitate mask ventilation during anesthetic induction. METHODS Patients undergoing elective surgery under general anesthesia were randomized into 2 groups. The midazolam group received midazolam premedication at the reception area, 3 minutes before transfer to the operating room. Patients in the control group were treated with normal saline as a placebo. The primary outcome was difficulty of mask ventilation during induction, as evaluated using the Warters scales. RESULTS A total of 97 patients completed the analysis: 49 in the control group and 48 in the midazolam group. The patients in the midazolam group showed a significantly lower mask ventilation difficulty score on the Warters scale than that of the control group (mean [standard deviation], 0.92 [1.13] vs 0.19 [0.57]; estimated difference [95% confidence interval], 0.73 [0.37-1.09]; P < .001). The incidence of difficult mask ventilation (≥2 Warters scale) was significantly lower in the midazolam group than in the control group (risk ratio [95% confidence interval], 0.15 [0.03-0.72]; P = .015). CONCLUSIONS This randomized clinical trial demonstrated that midazolam premedication enhanced mask ventilation during induction of general anesthesia. |
| Databáze: | OpenAIRE |
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