IL-28 and IL-29: Newcomers to the interferon family
| Autor: | Danièle Monneron, Gilles Uzé |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_treatment
Biology Antiviral Agents Models Biological Biochemistry Cell Line Interferon-gamma Interferon Cell surface receptor In vivo medicine Animals Humans Receptors Interleukin-10 Receptor Gene Models Genetic Janus kinase 1 Genome Human Interleukins General Medicine Cytokine Interleukin-21 receptor Immunology Cytokines Interferons Signal Transduction medicine.drug |
| Zdroj: | Biochimie. 89:729-734 |
| ISSN: | 0300-9084 |
| Popis: | IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity. Importantly, however, IFNs lambda bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This specific receptor usage suggests that this cytokine family does not merely replicate the type I IFN system and justifies its designation as type III IFN by the nomenclature committee of the International Society of Interferon and Cytokine Research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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