Trypsin and chymotrypsin as aids in the diagnosis of pancreatic disease
| Autor: | David M. Goldberg, A. Nigel Fawcett, Kenneth G. Wormsley, John K. Sale |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Pancreatic disease Physiology Duodenum Gastroenterology Secretin Internal medicine medicine Chymotrypsin Humans Trypsin Pancreas chemistry.chemical_classification biology business.industry Pancreatic Diseases General Medicine Hepatology medicine.disease Pancreatic Neoplasms Enzyme medicine.anatomical_structure Endocrinology chemistry Pancreatitis Gastrointestinal disease biology.protein business Cholecystokinin medicine.drug |
| Zdroj: | The American journal of digestive diseases. 17(9) |
| ISSN: | 0002-9211 |
| Popis: | One hundred and fifty-five tests were carried out on 70 patients using various regimens for stimulating the pancreas. Duodenal contents were quantitatively aspirated for determination of trypsin and chymotrypsin. Good discrimination between patients with pancreatic disease or pancreatic malfunction and patients with other gastrointestinal disease and normal pancreatic function was provided by measuring enzyme output during continuous intravenous infusion of 0.25 clinical units secretin together with 4 or 16 Crick, Harper, Raper units of cholecystokinin-pancreozymin per kilogram body weight each hour. The larger dose was occasionally associated with side effects; for routine purposes the smaller dose is satisfactory. Criteria for interpreting enzyme values are suggested. Trypsin output was more reliable than chymotrypsin as a diagnostic test, although determination of both was sometimes valuable. Estimation of enzyme concentration did not help to distinguish normal pancreatic function from abnormal function in the present series. |
| Databáze: | OpenAIRE |
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