The SOS system: A complex and tightly regulated response to DNA damage
Autor: | Iwona J. Fijalkowska, Karolina Makiela-Dzbenska, Katarzyna H. Maslowska |
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Rok vydání: | 2019 |
Předmět: |
Models
Molecular SOS response Epidemiology DNA damage Health Toxicology and Mutagenesis Mutagen Review 010501 environmental sciences Biology medicine.disease_cause 01 natural sciences Genome Genomic Instability 03 medical and health sciences chemistry.chemical_compound Bacterial Proteins TLS Escherichia coli medicine Animals Humans SOS Response Genetics Genetics (clinical) Derepression 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences RecA Bacteria fungi Mutagenesis mutator effect Bacterial Infections Gene Expression Regulation Bacterial LexA regulon Cell biology chemistry Genome Bacterial DNA DNA Damage |
Zdroj: | Environmental and Molecular Mutagenesis |
ISSN: | 1098-2280 0893-6692 |
Popis: | Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli , this inducible system is termed the SOS response. The SOS global regulatory network consists of multiple factors promoting the integrity of DNA as well as error‐prone factors allowing for survival and continuous replication upon extensive DNA damage at the cost of elevated mutagenesis. Due to its mutagenic potential, the SOS response is subject to elaborate regulatory control involving not only transcriptional derepression, but also post‐translational activation, and inhibition. This review summarizes current knowledge about the molecular mechanism of the SOS response induction and progression and its consequences for genome stability. Environ. Mol. Mutagen. 60:368–384, 2019. © 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society. |
Databáze: | OpenAIRE |
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