Improved prognostic stratification power of CIBMTR risk score with the addition of absolute lymphocyte and eosinophil counts at the onset of chronic GVHD
| Autor: | John Kuruvilla, Jieun Uhm, Joon Ho Moon, Sang Kyun Sohn, Vikas Gupta, Jeffrey H. Lipton, Matthew D. Seftel, Nada Hamad, Naheed Alam, Hans A. Messner, Dennis Dong Hwan Kim |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Lymphocyte Premedication Consensus criteria Graft vs Host Disease Gastroenterology Severity of Illness Index Prognostic stratification 03 medical and health sciences Leukocyte Count Young Adult 0302 clinical medicine Risk groups Internal medicine medicine Humans Transplantation Homologous Lymphocytes Mortality Aged Framingham Risk Score business.industry Hematopoietic Stem Cell Transplantation Hematology General Medicine Eosinophil Middle Aged Prognosis Survival Analysis Surgery Eosinophils medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Chronic Disease Chronic gvhd Female business Biomarkers Immunosuppressive Agents 030215 immunology |
| Zdroj: | Annals of hematology. 96(5) |
| ISSN: | 1432-0584 |
| Popis: | The CIBMTR chronic graft-versus-host disease (cGVHD) risk score can be refined and improved for better prognostic stratification. Three hundred and seven consecutive patients diagnosed with cGVHD by the NIH consensus criteria were retrospectively reviewed and had the CIBMTR risk score applied and analyzed. The CIBMTR risk score was successfully validated in our cohort (n = 307). The 3-year overall survival (OS) rates in each risk group (RG) were 82.5 ± 11.3% (RG1), 79.4 ± 3.0% (RG2), 71.8 ± 6.3% (RG3), and 27.3 ± 13.4% (RG4). A significantly lower OS rate and higher non-relapse mortality (NRM) were noted in RG4 compared to the other RGs. However, there were no differences in OS or NRM among RG1 to 3. To improve prognostic stratification power of the CIBMTR risk score, we incorporated the absolute lymphocyte (ALC) and eosinophil count (EC) at time of cGVHD into the CIBMTR risk score. Lower ALC ( |
| Databáze: | OpenAIRE |
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