Beyond temperature: controlling collagen fibrillogenesis under physiological conditions via interaction with cucurbit[7]uril
| Autor: | Qi Zeng, Qiuping Xie, Jinming Chang, Zhonghui Wang, Yi Chen, Delong Hou, Zhou Xu |
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| Rok vydání: | 2020 |
| Předmět: |
Bridged-Ring Compounds
Chemistry Tropocollagen Imidazoles Temperature Metals and Alloys Cavitand Fibrillogenesis General Chemistry Stimulus (physiology) Catalysis In vitro Surfaces Coatings and Films Electronic Optical and Magnetic Materials Hydrophobic effect Ionic strength In vivo Materials Chemistry Ceramics and Composites Biophysics Collagen Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Chemical Communications. 56:4946-4949 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Under physiological ionic strength and pH, temperature has long been appreciated as the only stimulus that can be applied to induce in vitro self-assembly of tropocollagen. Here, we report a second, mechanistically new control strategy that uses non-covalent and selective binding of cucurbit[7]uril, a macrocyclic cavitand, with midchain aromatic residues on the tropocollagen surface. This strategy directly demonstrates the decisive role hydrophobic interactions play in collagen fibrillogenesis. It also points the way to the temporally-controllable formation of collagen fibrils in vivo that is highly desirable, yet challenging, in some biomedical scenarios. |
| Databáze: | OpenAIRE |
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