Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process?
| Autor: | Gustavo Pereira de Sá, Moisés Evandro Bauer, Ivana Beatrice Mânica da Cruz, Alessandra Peres, Vanessa Moraes de Andrade, Margo Etiene Pazzato do Canto, Adriana Ritter dos Santos, Maristela Taufer, Graziela Oliveira |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Free Radicals Genotype DNA damage SOD2 Breast Neoplasms medicine.disease_cause Superoxide dismutase Prostate cancer Gene Frequency Antigens CD Risk Factors Internal medicine Cause of Death medicine Humans skin and connective tissue diseases Free-radical theory of aging Aged Aged 80 and over Alanine Polymorphism Genetic biology Superoxide Dismutase Infant Newborn Prostatic Neoplasms Valine Immunosenescence Free Radical Scavengers Middle Aged medicine.disease Oxidative Stress Endocrinology Immunology cardiovascular system biology.protein Female Geriatrics and Gerontology Oxidative stress DNA Damage |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 60(4) |
| ISSN: | 1079-5006 |
| Popis: | Oxidative stress has been related to aging. Recent evidences suggest that a genetic dimorphism that encodes for either alanine or valine in superoxide dismutase (SOD2) is involved with oxidative stress. However, the current literature is still controversial, and the potential role of the Ala16Val polymorphism in human aging needs to be established. Here we investigated the role of the SOD2 polymorphism in: a) age-related mortality, b) morbidity (breast and prostate cancer), c) immunological markers, and d) DNA damage in peripheral blood cells. We did not find an association between SOD2 polymorphisms and mortality. However, the AA genotype was associated with increased risk for prostate and breast cancer, immunosenescence profile, as well as DNA damage. These data suggest that SOD2 presents characteristics that support the free radical theory of aging. |
| Databáze: | OpenAIRE |
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