The temporal origin of dentate granule neurons dictates their role in spatial memory
| Autor: | Daniela Cota, Valérie Lemaire, Marie-Françoise Montaron, Fanny Farrugia, Shaoyu Ge, Sophie Tronel, Vanessa Charrier, Wilfrid Mazier, Giovanni Marsicano, Nicolas Blin, Cyril Herry, Nuria Masachs, Djoher Nora Abrous, Véronique Deroche-Gamonet |
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| Přispěvatelé: | Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Program in Neuroscience, SUNY at Stony Brook, stony brook, Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Stony Brook University [SUNY] (SBU), State University of New York (SUNY), tronel, sophie |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Neurons
0303 health sciences Dentate gyrus Period (gene) [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Cognition Optogenetics Biology Memory processing Rats Functional imaging 03 medical and health sciences Cellular and Molecular Neuroscience Psychiatry and Mental health 0302 clinical medicine Dentate Gyrus Animals Premovement neuronal activity [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Molecular Biology Neuroscience 030217 neurology & neurosurgery Spatial Memory 030304 developmental biology |
| Zdroj: | Molecular Psychiatry Molecular Psychiatry, Nature Publishing Group, 2021, ⟨10.1038/s41380-021-01276-x⟩ Molecular Psychiatry, Nature Publishing Group, 2021, 26 (12), pp.7130-7140. ⟨10.1038/s41380-021-01276-x⟩ |
| ISSN: | 1359-4184 1476-5578 |
| Popis: | The dentate gyrus is one of the only brain regions that continues its development after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated the role of dentate granule neurons (DGNs) born during adolescence in spatial memory and compared them with those generated earlier in life (in embryos or neonates) or during adulthood by combining functional imaging, retroviral and optogenetic tools to tag and silence DGNs. By imaging DGNs expressing Zif268, a proxy for neuronal activity, we found that neurons generated in adolescent rats (and not embryos or neonates) are transiently involved in spatial memory processing. In contrast, adult-generated DGNs are recruited at a later time point when animals are older. A causal relationship between the temporal origin of DGNs and spatial memory was confirmed by silencing DGNs in behaving animals. Our results demonstrate that the emergence of spatial memory depends on neurons born during adolescence, a function later assumed by neurons generated during adulthood. |
| Databáze: | OpenAIRE |
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