HIV incidence in a multinational cohort of men and transgender women who have sex with men in sub-Saharan Africa: Findings from HPTN 075

Autor: Karen Dominguez, Susan H. Eshleman, Ravindre Panchia, Vanessa Cummings, Ying Q. Chen, Wairimu Chege, Erica L. Hamilton, Eduard J. Sanders, Victor Akelo, Jonathan Lucas, Michael J. Stirratt, Theodorus G. M. Sandfort, Xu Guo, Yamikani Mbilizi, Charlotte A. Gaydos
Přispěvatelé: Global Health
Jazyk: angličtina
Rok vydání: 2021
Předmět:
RNA viruses
Male
Epidemiology
HIV Infections
Pathology and Laboratory Medicine
Transgender women
Men who have sex with men
Sexual and Gender Minorities
0302 clinical medicine
Immunodeficiency Viruses
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Longitudinal Studies
Prospective Studies
Virus Testing
Multidisciplinary
Chlamydia
Incidence
Hazard ratio
Hiv incidence
virus diseases
3. Good health
Infectious Diseases
Medical Microbiology
HIV epidemiology
Viral Pathogens
Viruses
Cohort
Female
Pathogens
Anatomy
0305 other medical science
Research Article
Medical conditions
Adult
Adolescent
Science
HIV prevention
Sex assignment
Sexually Transmitted Diseases
Men WHO Have Sex with Men
Viral diseases
Microbiology
Transgender Persons
03 medical and health sciences
Young Adult
Diagnostic Medicine
Retroviruses
Humans
Homosexuality
Male
Microbial Pathogens
Preventive medicine
030505 public health
Biology and life sciences
business.industry
Lentivirus
Organisms
Rectum
HIV
Correction
medicine.disease
Confidence interval
Gastrointestinal Tract
Public and occupational health
People and Places
Multivariate Analysis
Population Groupings
business
Digestive System
Sexuality Groupings
Demography
Zdroj: PLoS ONE, 16(2 February):e0247195. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247195 (2021)
Popis: Few studies have assessed HIV incidence in men who have sex with men (MSM) and transgender women (TGW) in sub-Saharan Africa (SSA). We assessed HIV incidence and its correlates among MSM and TGW in SSA enrolled in the prospective, multi-country HIV Prevention Trials Network (HPTN) 075 study, conducted from 2015 to 2017. Participants were enrolled at four sites in SSA (Kisumu, Kenya; Blantyre, Malawi; Cape Town and Soweto, South Africa). Eligible participants reported male sex assignment at birth, were 18 to 44 years of age, and had engaged in anal intercourse with a man in the preceding three months. Participation involved five study visits over 12 months. Visits included behavioral assessments and testing for HIV and sexually transmitted infections. Twenty-one of 329 persons acquired HIV during the study [incidence rate: 6.96/100 person-years (PY) (95% CI: 4.3, 10.6)]. Among TGW, HIV incidence was estimated to be 8.4/100 PY (95% CI: 2.3, 21.5). Four participants were found to have acute HIV infection at their first HIV-positive visit. HIV incidence varied among the four study sites, ranging from 1.3/100 PY to 14.4/100 PY. In multivariate longitudinal analysis, factors significantly associated with HIV acquisition were engagement in unprotected receptive anal intercourse [adjusted hazard ratio (AHR) 5.8, 95% confidence interval (CI): 2.4, 14.4] and incident rectal gonorrhea and/or chlamydia (AHR: 2.7, 95% CI: 1.1, 6.8). The higher HIV incidence in Cape Town compared to Blantyre could be explained by the higher prevalence of several risk factors for HIV infection among participants in Cape Town. Annual HIV incidence observed in this study is substantially higher than reported HIV incidence in the general populations in the respective countries and among MSM in the United States. Intensification of HIV prevention efforts for MSM and TGW in SSA is urgently needed.
Databáze: OpenAIRE
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