Persistent Human Papillomavirus Infection Is Associated with a Generalized Decrease in Immune Responsiveness in Older Women
| Autor: | Marcus Williams, Mark Schiffman, Ivannia Atmetlla, Ana Cecilia Rodriguez, Margarita Ramirez, Allan Hildesheim, Mariana Hildesheim, Maricela Villegas, Matthew T. Trivett, Jose Bonilla, Rolando Herrero, Enrique Freer, Jay A. Berzofsky, Robert D. Burk, Ligia A. Pinto, Alfonso J. García-Piñeres, Concepción Bratti |
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| Rok vydání: | 2006 |
| Předmět: |
Costa Rica
Cancer Research Sexual Behavior Population Disease Alphapapillomavirus Lymphocyte Activation Cohort Studies Antigen Humans Medicine education Aged Cervical cancer education.field_of_study Human papillomavirus 11 business.industry Papillomavirus Infections Age Factors Case-control study HPV infection virus diseases Middle Aged medicine.disease Oncology Case-Control Studies DNA Viral Immunology Female Viral disease business Cohort study |
| Zdroj: | Cancer Research. 66:11070-11076 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-06-2034 |
| Popis: | The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA–negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group (≥65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect. (Cancer Res 2006; 66(22): 11070-6) |
| Databáze: | OpenAIRE |
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