Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966
| Autor: | Hanna Korpela, Jussi Seppälä, Matti Isohanni, Tanja Nordström, Nina Rautio, Jouko Miettunen, Marjo-Riitta Järvelin, Juha Auvinen, Sirkka Keinänen-Kiukaanniemi, Erika Jääskeläinen |
|---|---|
| Přispěvatelé: | UNIVERSITY OF OULU |
| Rok vydání: | 2020 |
| Předmět: |
Male
Comorbidity Cohort Studies 0302 clinical medicine Risk Factors Medicine Cumulative incidence psychosis Finland 11 Medical and Health Sciences METABOLIC SYNDROME Psychiatry Incidence Incidence (epidemiology) Hazard ratio WOMEN BIPOLAR DISORDER FAMILY-STRUCTURE 17 Psychology and Cognitive Sciences 3. Good health Psychiatry and Mental health physical illnesses Schizophrenia Female Life Sciences & Biomedicine Research Article Cohort study Adult Affective Disorders Psychotic SINGLE-PARENT medicine.medical_specialty Psychosis somatic comorbidity 03 medical and health sciences Sex Factors cohort study Humans Risk factor MIDDLE-AGED MEN GENDER-DIFFERENCES PHYSICAL ILLNESS Science & Technology business.industry MORTALITY medicine.disease population-based 030227 psychiatry schizophrenia Psychotic Disorders RISK-FACTORS business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | European Psychiatry : the journal of the Association of European Psychiatrists |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | Background. We studied the cumulative incidence of physical illnesses, and the effect of early environmental factors (EEFs) on somatic comorbidity in schizophrenia, in nonschizophrenic psychosis and among nonpsychotic controls from birth up to the age of 50 years. Methods. The sample included 10,933 members of the Northern Finland Birth Cohort 1966, of whom, 227 had schizophrenia and 205 had nonschizophrenic psychosis. Diagnoses concerning physical illnesses were based on nationwide registers followed up to the end of 2016 and classified into 13 illness categories. Maternal education and age, family type at birth and paternal socioeconomic status were studied as EEFs of somatic illnesses. Results. When adjusted by gender and education, individuals and especially women with nonschizophrenic psychosis had higher risk of morbidity in almost all somatic illness categories compared to controls, and in some categories, compared to individuals with schizophrenia. The statistically significant adjusted hazard ratios varied from 1.27 to 2.42 in nonschizophrenic psychosis. Regarding EEFs, single-parent family as the family type at birth was a risk factor for a higher somatic score among men with schizophrenia and women with nonschizophrenic psychosis. Maternal age over 35 years was associated with lower somatic score among women with nonschizophrenic psychosis. Conclusions. Persons with nonschizophrenic psychoses have higher incidence of somatic diseases compared to people with schizophrenia and nonpsychotic controls, and this should be noted in clinical work. EEFs have mostly weak association with somatic comorbidity in our study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|