The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK

Autor: Robab Davar, Irene Di Ceglie, Lisa-Marie Böttcher, Johannes Roth, Thomas Vogl, Arjen B. Blom, Ehsan Habibi, Peter L E M van Lent, Martijn H J van den Bosch, Peter M. van der Kraan, Carl S. Goodyear, Joost H.A. Martens, Colin Logie
Rok vydání: 2019
Předmět:
0301 basic medicine
Lipopolysaccharide Receptors
Osteoclasts
Biology
Biochemistry
Monocytes
S100A9
Bone resorption
S100A8
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Osteoclast
parasitic diseases
Genetics
medicine
Calgranulin B
Humans
Rank (graph theory)
Epigenetics
Bone Resorption
S100a8 a9
Molecular Biology
Inflammation
Receptor Activator of Nuclear Factor-kappa B
Tumor Necrosis Factor-alpha
Macrophage Colony-Stimulating Factor
RANK Ligand
Cell Differentiation
Recombinant Proteins
Histone Code
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
Cancer research
Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
030217 neurology & neurosurgery
Interleukin-1
Biotechnology
Zdroj: The Faseb Journal, 33, 9, pp. 10104-10115
The Faseb Journal, 33, 10104-10115
ISSN: 1530-6860
0892-6638
Popis: The alarmin S100A8/A9 is implicated in sterile inflammation-induced bone resorption and has been shown to increase the bone-resorptive capacity of mature osteoclasts. Here, we investigated the effects of S100A9 on osteoclast differentiation from human CD14
Databáze: OpenAIRE
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