Emergence of X4 usage among HIV-1 subtype C: evidence for an evolving epidemic in South Africa
| Autor: | Willem D F Venter, Maria A. Papathanasopoulos, Wendy S. Stevens, Katherine Michler, Bridgette Janine Connell, Alexio Capovilla |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Receptors CXCR4 Genotype Receptors CCR5 viruses Immunology Molecular Sequence Data V3 loop Genes env Giant Cells Virus Disease Outbreaks Cohort Studies South Africa Genotype-phenotype distinction Acquired immunodeficiency syndrome (AIDS) medicine Immunology and Allergy Humans Amino Acid Sequence Acquired Immunodeficiency Syndrome Phylogenetic tree biology Base Sequence business.industry virus diseases Middle Aged biology.organism_classification medicine.disease Phenotype Virology Infectious Diseases Lentivirus DNA Viral HIV-1 Female Viral disease business |
| Zdroj: | AIDS (London, England). 22(7) |
| ISSN: | 1473-5571 |
| Popis: | This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African AIDS patients. We found the highest percentage of CXCR4 usage among primary isolates, in which 30% efficiently utilized CXCR4 and exhibited the syncytium-inducing phenotype. Phylogenetic analysis of env confirmed that 19 of the 20 were subtype C, and syncytium-inducing viruses had genetic changes in the V3 loop, characteristic of CXCR4 usage. Results imply that the frequency of CXCR4-utilizing subtype C is increasing with time. |
| Databáze: | OpenAIRE |
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