Immunopathology of Schistosoma japonicum and S. mansoni infection in B cell depleted mice
| Autor: | A. W. Cheever, Sara Hieny, J. E. Byram, Alan Sher, M. N. Lunde, F. Von Lichtenberg |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Time Factors Immunology Mice Nude Antigens Protozoan Schistosoma japonicum Mice Immune system Antigen Fibrosis parasitic diseases medicine Animals Schistosomiasis Parasite Egg Count B cell B-Lymphocytes Granuloma biology Liver Diseases Age Factors Schistosoma mansoni medicine.disease biology.organism_classification medicine.anatomical_structure biology.protein Female Parasitology Antibody Hepatic fibrosis |
| Zdroj: | Parasite Immunology. 7:399-413 |
| ISSN: | 1365-3024 0141-9838 |
| DOI: | 10.1111/j.1365-3024.1985.tb00086.x |
| Popis: | To investigate the role of antibody in the pathogenesis of hepatic granulomas around schistosome eggs, mice were depleted of B cells by treatment from birth with anti-IgM serum and were subsequently infected with Schistosoma japonicum or S. mansoni. Anti-IgM treatment did not affect the development or fecundity of the worms or the larvae within the egg shells. Normal circumoval granulomas were present in the livers of B cell depleted mice 7 or 8 weeks after infection clearly indicating that antibody and immune complexes have no necessary role in the formation of granulomas. Hepatic fibrosis was also similar in B cell depleted and untreated mice at these times. Ten weeks after infection the size of S. japonicum egg granulomas in untreated mice had decreased but no change in the size of granulomas had occurred in B cell depleted mice, and hepatic fibrosis was more marked in treated than in untreated mice. Similar changes were noted in S. mansoni infected mice, assayed at 8 and at 12-13.5 weeks after infection. The effects of B cell depletion in the more chronic infections may be related to the absence of antibody but could also be caused by an influence on B cell-dependent suppressor T cells. |
| Databáze: | OpenAIRE |
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