Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Autor: | Arthur W. Musk, John P. Kemp, Ioanna Ntalla, Igor Rudan, Suzanne Miller, Anubha Mahajan, Samuli Ripatti, Nicholas J. Wareham, Alan F. Wright, Jennie Hui, Jing Hua Zhao, Jonathan Marten, Olli T. Raitakari, Henry Voelzke, John Beilby, John M. Starr, Robert A. Scott, Harry Campbell, Ma'en Obeidat, Deborah Jarvis, David C. Nickle, Markku Heliövaara, Nick Shrine, Lars Lind, David M. Evans, Richard Hubbard, John Henderson, Ozren Polasek, Panos Deloukas, James F. Wilson, María Soler Artigas, Ian P. Hall, Jennifer E. Huffman, Juan R. González, Joachim Heinrich, Mika Kähönen, Tim D. Spector, Neil C. Thomson, Christopher J Hammond, Marjo-Riitta Järvelin, Erik Ingelsson, Stefan Enroth, Ida Surakka, Andrew P. Morris, Ivana Kolcic, Louise V. Wain, Sarah H. Wild, Lynne J. Hocking, Wendy L. McArdle, Rajesh Rawal, Nina Hutri-Kähönen, Tatijana Zemunik, Åsa Johansson, Terho Lehtimäki, Christian Gieger, Veronique Vitart, Erik Melén, Sarah E. Harris, Medea Imboden, Holly Trochet, Momoko Horikoshi, Don D. Sin, Ian J. Deary, Pau Navarro, Alexessander Couto Alves, Ashok Kumar, Abdul Kader Kheirallah, Caroline Hayward, Stefan Karrasch, Alan James, Alexander Teumer, Ulf Gyllensten, Victoria E. Jackson, Eleftheria Zeggini, Ian D. Pavord, Holger Schulz, Anna-Liisa Hartikainen, Ana Viñuela, Anna Hansell, Nicole Probst-Hensch, Leo-Pekka Lyytikäinen, Pirro G. Hysi, Ian Sayers, Jonathan Marchini, Claudia Flexeder, David P. Strachan, Martin D. Tobin, Raquel Granell, Beate Stubbe, Corry-Anke Brandsma, Sven Glaeser, Janina S. Ried, Eva Albrecht, Yohan Bossé, Peter K. Joshi, Lorna M. Lopez, Sandosh Padmanabhan, Harald Grallert |
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Přispěvatelé: | Medical Research Council (MRC), Groningen Research Institute for Asthma and COPD (GRIAC), Institute for Molecular Medicine Finland, Clinicum, Department of Public Health, Biostatistics Helsinki, Complex Disease Genetics |
Rok vydání: | 2015 |
Předmět: |
Lung Diseases
Male Vital capacity UK BiLEVE General Physics and Astronomy Genome-wide association study 0302 clinical medicine Missing heritability problem MISSING HERITABILITY Forced Expiratory Volume Genotype SEQUENCE VARIANTS WIDE ASSOCIATION SUSCEPTIBILITY LOCUS Lung GENE-EXPRESSION Genetics Aged 80 and over 0303 health sciences ARCHITECTURE Multidisciplinary Middle Aged Aparell respiratori 3. Good health ddc Multidisciplinary Sciences Science & Technology - Other Topics Female Adult European Continental Ancestry Group Biology OBSTRUCTIVE PULMONARY-DISEASE Polymorphism Single Nucleotide White People Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences FEV1/FVC ratio Young Adult MD Multidisciplinary Humans SMOKING-BEHAVIOR 1000 Genomes Project Genetik METAANALYSIS 030304 developmental biology Aged Science & Technology spirometry lung function genetics ta1184 General Chemistry ta3121 Heritability 030228 respiratory system 3121 General medicine internal medicine and other clinical medicine Pulmons FORCED VITAL CAPACITY Imputation (genetics) Genètica Genome-Wide Association Study |
Zdroj: | Nature Communications, 6:8658. Nature Publishing Group Artigas, M S, Wain, L V, Miller, S, Kheirallah, A K, Huffman, J E, Ntalla, I, Shrine, N, Obeidat, M, Trochet, H, McArdle, W L, Alves, A C, Hui, J, Zhao, J H, Joshi, P K, Teumer, A, Albrecht, E, Imboden, M, Rawal, R, Lopez, L M, Marten, J, Enroth, S, Surakka, I, Polasek, O, Lyytikäinen, L-P, Granell, R, Hysi, P G, Flexeder, C, Mahajan, A, Beilby, J, Bossé, Y, Brandsma, C-A, Campbell, H, Gieger, C, Gläser, S, González, J R, Grallert, H, Hammond, C J, Harris, S E, Hartikainen, A-L, Henderson, J, Navarro, P, Starr, J M, Wild, S H, Wright, A F, Vitart, V, Rudan, I, Deary, I J, Wilson, J F & Morris, A P & Hayward, C 2015, ' Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation ', Nature Communications, vol. 6, pp. 8658 . https://doi.org/10.1038/ncomms9658 Nature Communications Artigas, M S, Wain, L V, Miller, S, Kheirallah, A K, Huffman, J E, Ntalla, I, Shrine, N, Obeidat, M, Trochet, H, McArdle, W L, Alves, A C, Hui, J, Zhao, J H, Joshi, P K, Teumer, A, Albrecht, E, Imboden, M, Rawal, R, Lopez, L M, Marten, J, Enroth, S, Surakka, I, Polasek, O, Lyytikäinen, L P, Granell, R, Hysi, P G, Flexeder, C, Mahajan, A, Beilby, J, Bossé, Y, Brandsma, C A, Campbell, H, Gieger, C, Gläser, S, González, J R, Grallert, H, Hammond, C J, Harris, S E, Hartikainen, A L, Heliövaara, M, Henderson, J, Hocking, L, Horikoshi, M, Hutri-Kähönen, N, Ingelsson, E, Johansson, Å, Kemp, J P, Kolcic, I, Kumar, A, Lind, L, Melén, E, Musk, A W, Navarro, P, Nickle, D C, Padmanabhan, S, Raitakari, O T, Ried, J S, Ripatti, S, Schulz, H, Scott, R A, Sin, D D, Starr, J M, Viñuela, A, Völzke, H, Wild, S H, Wright, A F, Zemunik, T, Jarvis, D L, Spector, T D, Evans, D M, Lehtimäki, T, Vitart, V, Kähönen, M, Gyllensten, U, Rudan, I, Deary, I J, Karrasch, S, Probst-Hensch, N M, Heinrich, J, Stubbe, B, Wilson, J F, Wareham, N J, James, A L, Morris, A P, Jarvelin, M R, Hayward, C, Sayers, I, Strachan, D P, Hall, I P, Tobin, M D, Deloukas, P, Hansell, A L, Hubbard, R, Jackson, V E, Marchini, J, Pavord, I, Thomson, N C & Zeggini, E 2015, ' Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation ', Nature Communications, vol. 6, 89658 . https://doi.org/10.1038/ncomms9658 |
ISSN: | 2041-1723 |
Popis: | Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function. |
Databáze: | OpenAIRE |
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