Is Disease Activity in Rheumatoid Arthritis during Pregnancy and after Delivery Predictive for Disease Activity in a Subsequent Pregnancy?
| Autor: | Johanna M. W. Hazes, Radboud J E M Dolhain, Hilal Ince-Askan |
|---|---|
| Přispěvatelé: | Rheumatology |
| Rok vydání: | 2015 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pregnancy High-Risk Immunology Prospective data Gestational Age Disease Risk Assessment Severity of Illness Index Arthritis Rheumatoid Cohort Studies Disease activity 03 medical and health sciences 0302 clinical medicine Rheumatology Predictive Value of Tests Pregnancy Internal medicine medicine Humans Immunology and Allergy Prospective Studies skin and connective tissue diseases 030203 arthritis & rheumatology business.industry Postpartum Period Pregnancy Outcome First pregnancy Prenatal Care medicine.disease Surgery Pregnancy Complications Parity 030104 developmental biology Rheumatoid arthritis Female Subsequent pregnancy Previous pregnancies business Follow-Up Studies |
| Zdroj: | Journal of Rheumatology, 43(1), 22-25. Journal of Rheumatology |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.150565 |
| Popis: | Objective.To determine whether disease activity in women with rheumatoid arthritis (RA) in 1 pregnancy is predictive for disease activity in a subsequent pregnancy.Methods.In the Pregnancy-induced Amelioration of Rheumatoid Arthritis study, there are prospective data on 27 patients who participated twice. Improvement and deterioration is determined by changes in the Disease Activity Score in 28 joints.Results.Only 4 patients (14.8%) had comparable disease courses in both pregnancies, whereas treatment remained mostly similar. In contrast, a flare postpartum after the first pregnancy was predictive for a flare after the second pregnancy (p = 0.003).Conclusion.RA disease course in following pregnancies cannot be predicted based upon previous pregnancies. However, a flare postpartum seems to predict subsequent flares. |
| Databáze: | OpenAIRE |
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