Higher prevalence of splenic artery aneurysms in hereditary hemorrhagic telangiectasia: Vascular implications and risk factors
| Autor: | Mostafa El Hajjam, Florent Soubrier, Augustin Ozanne, Gilles Lesur, Alain Beauchet, Philippe Charron, Pascal Lacombe, Aurélien Palmyre, Isabelle Bourgault-Villada, Jerome Lucas, Jérome Lesniak, Axel Dallongeville, Carole Fagnou, J. Sellier, Carma Karam, S. Binsse, Thierry Chinet, Mélanie Eyries, Sandra Blivet, Agnès Nicod-Tran |
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| Přispěvatelé: | Hôpital Ambroise Paré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Epidemiology Physiology Maternal Health Blood Pressure Disease Cardiovascular Medicine Splenic artery Vascular Medicine Gastroenterology Diagnostic Radiology 030218 nuclear medicine & medical imaging 0302 clinical medicine Risk Factors Pregnancy Blood Flow hemic and lymphatic diseases Prevalence Medicine and Health Sciences Telangiectasia Tomography Multidisciplinary Radiology and Imaging Obstetrics and Gynecology Arteries Middle Aged Prognosis Body Fluids 3. Good health Blood Cardiovascular Diseases Hypertension Medicine Female Telangiectasia Hereditary Hemorrhagic France Anatomy medicine.symptom Aneurysms Research Article Adult medicine.medical_specialty Imaging Techniques Science Neuroimaging Research and Analysis Methods 03 medical and health sciences Hypertensive Disorders in Pregnancy Diagnostic Medicine Internal medicine medicine.artery Multidetector Computed Tomography medicine Humans Vascular Diseases Aged Retrospective Studies Fetus Aorta business.industry Case-control study Biology and Life Sciences Retrospective cohort study Blood flow Aneurysm Computed Axial Tomography 030104 developmental biology Case-Control Studies Medical Risk Factors Cardiovascular Anatomy Blood Vessels Women's Health [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Splenic Artery Follow-Up Studies Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2020, 15 (1), pp.e0226681. ⟨10.1371/journal.pone.0226681⟩ PLoS ONE, Vol 15, Iss 1, p e0226681 (2020) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0226681⟩ |
| Popis: | International audience; Background: Splenic artery aneurysm (SAA) is a rare but potentially fatal condition. Rupture results in 25% mortality up to 75% in pregnant women with 95% fetal mortality. Brief reports suggest an increased risk of developing SAA in patients with HHT.Methods: We analyzed enhanced multidetector CT data in 186 HHT patients matched (gender and ± 5 year old) with 186 controls. We screened for SAA and recorded diameter of splenic and hepatic arteries and hepatic, pancreatic and splenic parenchymal involvements. We determined by univariate and multivariate analysis, the relationship with age, sex, genetic status, cardiovascular risk factors (CVRF) and visceral involvement.Results: SAA concerned 24.7% of HHT patients and 5.4% of controls, p |
| Databáze: | OpenAIRE |
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