Adaptive Focused Acoustics™ for Nanosuspensions to Enable Pharmacology Assessment of Poorly Soluble Molecules in Lead Optimization
| Autor: | Andrey Peresypkin, Setu Roday, Stavropoulos Kathy, Wojciech Dworakowski, Nti-Addae Kwame Wiredu, Elisabeth Doyle, Jim Bernhard |
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| Rok vydání: | 2020 |
| Předmět: |
Drug discovery
Chemistry Pharmaceutical Science 02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Solubility Suspensions Preclinical pharmacokinetics Nanomedicine Animals Nanoparticles Particle Size 0210 nano-technology |
| Zdroj: | Journal of pharmaceutical sciences. 110(7) |
| ISSN: | 1520-6017 |
| Popis: | In Drug Discovery, pharmacology studies often require benign formulation compositions for safe administration in animal models. Here, we applied Adaptive Focused Acoustics™ (AFA) to a molecular scaffold with challenging physicochemical properties for intraperitoneal administration. Nanosuspensions can be prepared at small scales and provide broad applicability. Our results show that nanosuspension formulations prepared by AFA have improved PK performance relative to a DMSO solution formulation that is prone to precipitation in-vivo. |
| Databáze: | OpenAIRE |
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