Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study
| Autor: | Deborah Goodman, Daphne Thampy, Andrea Alvarez, Diane Heditsian, Susie Brain, Irene Masunaka, Asana Pebdani, Rachel McFarland Lucia, Melodie Elyasian, Vivian S. Lee, Amanda Hidajat, Hannah Lui Park, Trina M. Norden-Krichmar, Danielle Forman, Andrew O. Odegaard, Argyrios Ziogas, Kailynn June Yang, Wei Lin Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Aging
Health Toxicology and Mutagenesis lcsh:Medicine Disease Toxicology Cohort Studies 0302 clinical medicine Medicine 2.2 Factors relating to the physical environment Aetiology Cancer 0303 health sciences education.field_of_study DNA methylation 030220 oncology & carcinogenesis Cohort Biomarker (medicine) biomarker Female environmental exposures Record linkage Pediatric Research Initiative Population Article 03 medical and health sciences Clinical Research Environmental health Breast Cancer Genetics Humans Pesticides education biorepository 030304 developmental biology Nutrition Postmenopausal women epigenetics business.industry Prevention lcsh:R Public Health Environmental and Occupational Health Environmental Exposure Biorepository Cross-Sectional Studies Good Health and Well Being Generic health relevance business Health questionnaire Biomarkers 2.4 Surveillance and distribution |
| Zdroj: | International journal of environmental research and public health, vol 17, iss 5 International Journal of Environmental Research and Public Health Volume 17 Issue 5 International Journal of Environmental Research and Public Health, Vol 17, Iss 5, p 1774 (2020) |
| Popis: | Environmental factors have been linked to many diseases and health conditions, but reliable assessment of environmental exposures is challenging. Developing biomarkers of environmental exposures, rather than relying on self-report, will improve our ability to assess the association of such exposures with disease. Epigenetic markers, most notably DNA methylation, have been identified for some environmental exposures, but identification of markers for additional exposures is still needed. The rationale behind the Markers for Environmental Exposures (MEE) Study was to (1) identify biomarkers, especially epigenetic markers, of environmental exposures, such as pesticides, air/food/water contaminants, and industrial chemicals that are commonly encountered in the general population and (2) support the study of potential relationships between environmental exposures and health and health-related factors. The MEE Study is a cross-sectional study with potential for record linkage and follow-up. The well-characterized cohort of 400 postmenopausal women has generated a repository of biospecimens, including blood, urine, and saliva samples. Paired data include an environmental exposures questionnaire, a breast health questionnaire, dietary recalls, and a food frequency questionnaire. This work describes the rationale, study design, and cohort characteristics of the MEE Study. In addition to our primary research goals, we hope that the data and biorepository generated by this study will serve as a resource for future studies and collaboration. |
| Databáze: | OpenAIRE |
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