Plasma Clusterin Concentrations May Predict Resistance to Intravenous Immunoglobulin in Patients with Kawasaki Disease
| Autor: | Ho-Chang Kuo, I-Chun Lin, Chih-Cheng Chen, Jiunn-Ming Sheen, Ying-Hsien Huang, Ying-Jui Lin, Mei-Chen Ou-Yang, Hong-Ren Yu, Fu-Chen Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Article Subject lcsh:Medicine Mucocutaneous Lymph Node Syndrome Gastroenterology lcsh:Technology General Biochemistry Genetics and Molecular Biology Young Adult Internal medicine hemic and lymphatic diseases medicine Humans In patient Young adult Child lcsh:Science General Environmental Science Clusterin biology Receiver operating characteristic business.industry lcsh:T lcsh:R Immunoglobulins Intravenous Infant General Medicine medicine.disease Confidence interval Child Preschool Immunology Clinical Study biology.protein Biomarker (medicine) Female Kawasaki disease lcsh:Q Antibody business Biomarkers |
| Zdroj: | The Scientific World Journal, Vol 2013 (2013) The Scientific World Journal |
| Popis: | Kawasaki disease (KD) is an acute febrile vasculitic syndrome of early childhood often complicated by coronary artery lesion that drastically reduces the quality of life. The study aimed to identify a reliable marker for predicting nonresponsiveness to the first course of intravenous immunoglobulin (IVIG) in KD patients. A total of 63 patients with KD were enrolled in the study (IVIG response, 58; IVIG resistance, 5). Plasma samples were collected before and after IVIG infusion for measurement of biomarkers. Patients’ clinical characteristics and laboratory data were also analyzed. A receiver operating characteristic curve was generated to identify a cut-off value for predicting IVIG resistance. Among the biomarkers, the difference in plasma clusterin concentrations before and after IVIG infusion (CLUSTER 12) was significantly related to IVIG resistance (P=0.040; 95% confidence interval (CI): −25.8% to −6.0%). Using a CLUSTER 12 cut-off value of 8.52 mg/L had a much higher risk of IVIG resistance than those with CLUSTER 12 concentrations |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|