Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation:a pilot study in porcines
| Autor: | Juan Manuel Shiguetomi-Medina, Ahmed Abdul-Hussein Abood, Hans Stødkilde-Jørgensen, Ole Rahbek, Casper Bindzus Foldager, Bjarne Møller-Madsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cartilage graft Bone bridges Fibrin 03 medical and health sciences 0302 clinical medicine Basic Science medicine Fat grafting Orthopedics and Sports Medicine Fat graft 030222 orthopedics biology business.industry bone bridges Cartilage Sealant 030229 sport sciences fat graft Surgery medicine.anatomical_structure Pediatrics Perinatology and Child Health biology.protein Bone bridge cartilage graft business |
| Zdroj: | Abood, A A-H, Møller-Madsen, B, Shiguetomi Medina, J M, Stødkilde-Jørgensen, H, Foldager, C B & Rahbek, O 2020, ' Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation : a pilot study in porcines ', Journal of Children's Orthopaedics, vol. 14, no. 5 . https://doi.org/10.1302/1863-2548.14.200024 Journal of Children's Orthopaedics Abood, A A, Møller-Madsen, B, Shiguetomi-Medina, J M, Stødkilde-Jørgensen, H, Foldager, C & Rahbek, O 2020, ' Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation – a pilot study in porcines ', Journal of children's orthopaedics, vol. 14, no. 5, pp. 459-465 . https://doi.org/10.1302/1863-2548.14.200024 |
| DOI: | 10.1302/1863-2548.14.200024 |
| Popis: | Purpose The article compares physeal recovery after insertion of autologous cartilage and a conventional fat graft in a standardized porcine physeal gap model. Presence of a bone bridge was the primary outcome. Methods Ten porcines in two groups of five were included in a paired design. A standardized physeal gap in the distal femur was made in all animals. One group (n = 5) was randomized for deposition of autologous cartilage and a Tisseel® or Tisseel® alone. The autologous cartilage was harvested from the femoral articular surface. The other group was randomized for fat grafting or no grafts at all. All animals were housed for 14 weeks. Magnetic resonance imaging (MRI) was performed at 14 weeks prior to euthanasia. The physis was harvested for histology. Results MRI – Three bone bridges were seen in the fat grafted gaps. All empty gaps formed a bone bridge. No gaps filled with autologous cartilage and Tisseel® resulted in bone bridges. One gap filled with Tisseel® only caused a bone bridge. Histology – The cartilage grafted gaps recovered with physeal-like cartilaginous tissue in histological analysis. Conclusions Fat grafts seems ineffective in preventing bone bridges. The use of autologous cartilage may be superior to the current treatment. However, donor site complications were not investigated. The study serves as a proof of concept study and requires further investigation. Level of evidence III |
| Databáze: | OpenAIRE |
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