Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Autor: Karen Y. Stokes, Phillip C. S. R. Kilgore, Lana Larmeu, Vinita Batra, Tyler H. Reekes, J. Steven Alexander, Shuai Yuan, Roger E. Kelley, Elizabeth A. Disbrow, Christopher G. Kevil, Christina Ledbetter, Urska Cvek, Marjan Trutschl, James C. Patterson, Sibile Pardue
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Heart disease
Vascular homeostasis
Epidemiology
White matter lesion
brain volume
Disease
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Alzheimer Disease
Internal medicine
FLAIR
medicine
Humans
Dementia
Cognitive Dysfunction
Hydrogen Sulfide
Aged
ADAS‐cog
Total plasma
Featured Articles
H2S
business.industry
Health Policy
Middle Aged
Featured Article
equipment and supplies
medicine.disease
Magnetic Resonance Imaging
White Matter
United States
Psychiatry and Mental health
030104 developmental biology
Potential biomarkers
Biomarker (medicine)
Female
Cognitive function
Neurology (clinical)
Geriatrics and Gerontology
business
Biomarkers
030217 neurology & neurosurgery
MRI
Zdroj: Alzheimer's & Dementia
ISSN: 1552-5279
1552-5260
Popis: While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.
Scheme for sulfide dysregulation in ADRD. In ADRD, increased accumulation of sulfides, measured in plasma, may reflect increased formation of H2S metabolites produced in the vascular compartment. Several sulfide species are known to impair blood brain barrier leading to persistent excitotoxic stress and subsequent destructive changes in brain microvascular structure and cognitive function seen in ADRD.
Databáze: OpenAIRE
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