Mitral annular calcification and the serum osteocalcin level in patients with chronic kidney disease

Autor:	Murat Celik, Tayfun Eyileten, Mahmut Gok, Hakki Cetinkaya, Yalçın Gökoğlan, Mahmut Ilker Yilmaz, Yusuf Oguz, Hilmi Umut Unal, Murat Karaman
Rok vydání:	2014
Předmět:	Adult Male medicine.medical_specialty Mitral annular calcification Lymphocyte Osteocalcin Heart Valve Diseases Critical Care and Intensive Care Medicine Gastroenterology Internal medicine Humans Medicine In patient Renal Insufficiency Chronic Retrospective Studies biology medicine.diagnostic_test business.industry Calcinosis Red blood cell distribution width General Medicine Middle Aged medicine.disease C-Reactive Protein Logistic Models Endocrinology medicine.anatomical_structure Echocardiography Nephrology Calcitonin Erythrocyte sedimentation rate biology.protein Mitral Valve Female business Biomarkers Kidney disease
Zdroj:	Renal Failure. 36:1481-1485
ISSN:	1525-6049 0886-022X
Popis:	To determine the relationships between inflammatory mediators, mitral annular calcification (MAC), and osteocalcin in patients with chronic kidney disease (CKD).Echocardiographic data for 60 patients diagnosed as CKD were retrospectively evaluated. The patients were divided into 2 groups; patients with MAC (MAC+ group) and patients without MAC (MAC- group). The relationships between biochemical markers-including osteocalcin-and MAC were evaluated.The study included 19 female and 41 male patients. In all, 29 patients were MAC+ and 31 were MAC-. High-sensitive C-reactive protein (hsCRP) and osteocalcin levels were significantly higher in the MAC+ group (p 0.05). The eGFR was lower, serum calcitonin (we could not obtain calcitonin data for 15 patients), Ca, PO4, CaxPO4, the erythrocyte sedimentation rate, red cell distribution width, the neutrophil/Lymphocyte rate, and PTH were higher in the MAC+ group; however, the differences between the groups were not significant (p 0.05). The mitral E/A ratio, mitral peak Ea velocity, tricuspid E/A ratio, hsCRP, and the osteocalcin level were strongly correlated with MAC. Multivariate logistic regression analysis showed that only the osteocalcin level and mitral E/A ratio were independent variables, each with an independent effect on MAC.CKD patients in the MAC+ group had higher osteocalcin levels than those in the MAC- group, and left ventricular diastolic dysfunction was more common in the MAC+ group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a491321afbb30807bcd259e5109111 https://doi.org/10.3109/0886022x.2014.962421 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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