Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review
| Autor: | Madelaine Skolastika Theardy, Sharleen Elvira, Evelyn Nathalia, Graciella Rosellinny, Anton Sumarpo, Michael Putra Utama, Andrew Steven Liyanto |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tumor suppressor gene Mesenchyme LIM-Homeodomain Proteins lhx6 Down-Regulation Nerve Tissue Proteins medicine.disease_cause Metastasis 03 medical and health sciences Internal medicine Neoplasms Biomarkers Tumor Medicine Humans Genes Tumor Suppressor tumor suppressor gene prognostic biomarker Transcription factor epigenetics business.industry Wnt signaling pathway Cancer medicine.disease cancer progression RC31-1245 030104 developmental biology medicine.anatomical_structure embryonic structures Cancer research Homeobox business Carcinogenesis Transcription Factors |
| Zdroj: | Romanian Journal of Internal Medicine, Vol 56, Iss 3, Pp 135-142 (2018) |
| ISSN: | 1220-4749 |
| Popis: | Introduction. LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has been reported to play a role in cancer progression. This narrative review summarizes literatures that emphasize the molecular regulation of LHX6 in tumorigenesis. Methods. In our systematic review, the PubMed database was used for the literature search using the combination of words that included “LHX6” and “cancer”. Relevant studies, including in vitro, in vivo experiments, and clinical studies, were analyzed in this review. Results. We found evidences that LHX6 might be important in the inhibition of tumor cell proliferation, growth, invasion, and metastasis through the suppression of Wnt/β-catenin signaling pathway. Moreover, LHX6 is observed to be downregulated in certain types of cancer due to hypermethylation, thus hindering its tumor suppressing ability. In addition, hypermethylation can also be used to determine the stage of cancer development. Conclusion. The downregulation of LHX6 expression might be responsible in promoting cancer progression. Future studies are necessary to investigate the potential of LHX6 as a novel cancer biomarker as well as its therapeutic implications towards certain types of cancer. |
| Databáze: | OpenAIRE |
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